Study of diabetic maculopathy by focal lmacular ERG

局灶黄斑ERG研究糖尿病性黄斑病变

• 批准号: 04454440
• 负责人: MIYAKE Yozo
• 金额: $ 3.71万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454440/
• 关键词: Focal macular ERG; Diabetic macularpatting; Layr-by-layr analysis; inner layr; outer layr; Diabetic macular edema; Oscillatory Potentials; 糖尿病網膜症; 黄斑浮腫; 層別診断; 先天網膜分離; 類のう胞黄斑浮腫; 中心性漿液性脈絡網膜症; 無水晶体性黄斑浮腫; 糖尿病性黄斑症; α波; b波

We have succeeded to record a-wave, b-wave and oscillatory potentials (OPs) in human macular region, using the focal amcular ERG recording system developed by us. The analysis of these components can provide the layr-by-layr diagnosis of the macular diseases. The purpose of this study is to investigate the pathogenesis of the diabetic maculopathy with this system. Before analylzing diabetic maculopathy, we studied the inner layr disease (congenital retinoschisis and aphakic cystoid macular edema) and outer retinal disease (central serous chorioretinopathy) to know the properties of focal macular ERG in theses known diseases. The results indicated that in outer retinal disease, all components of ERG were deteriorated, even when the visual acuity was relatively good. On the othger hand, in inner retinal diseases, the OPs were the most sensitively deteriorated, followed by the deteriration of the b-wave and a-wave. In diabetic macular edema, the focal macular ERG showed combined onner and outer retinal layr disturbance in many patients, indicating that the edema excists not only in the inner retinal layr, but also in the outer retinal layr.

利用自行研制的焦-肌ERG记录系统，成功地记录了人黄斑区的a波、b波和振荡电位(OPs)。对这些成分的分析可以提供黄斑疾病的逐层诊断。本研究的目的是利用该系统研究糖尿病黄斑病变的发病机制。在分析糖尿病黄斑病变之前，我们研究了内层病变(先天性视网膜劈裂和无晶状体性黄斑囊样水肿)和外层视网膜病变(中心性浆液性脉络膜视网膜病变)，以了解局灶性黄斑ERG在这些已知疾病中的特点。结果表明，在视网膜外部疾病中，即使在视力较好的情况下，ERG的所有成分也会恶化。另一方面，在视网膜内层疾病中，OPS的恶化最为敏感，其次是b波和a波的抑制。在糖尿病黄斑水肿中，许多患者的黄斑ERG表现为视网膜内层和外层并存，表明黄斑水肿不仅存在于视网膜内层，也存在于视网膜外层。

项目成果

Miyake Y,Shiroyama N et al: "Focal macular electro retinogram in x-linked congenital retinoschisis" Invest Ophthalmol Vis Sci. 34. 512-515 (1993)

Miyake Y、Shiroyama N 等人：“x 连锁先天性视网膜劈裂中的局灶性黄斑视网膜电图”Invest Ophthalmol Vis Sci。

Miyake Y,Miyake K et al: "Classification of aphakic cystoid macular edema with focal macular electroretinograms" Am J Ophthalmol. 116. 576-583 (1993)

Miyake Y、Miyake K 等人：“通过局灶性黄斑视网膜电图对无晶状体囊样黄斑水肿进行分类”Am J Ophthalmol。

Miyake Y, Miyake K and Shiroyama N.: "Clasification of aphakec cystoid macular edema with focal macular electroretinogram." Am J Ophthalmol. 116. 576-583 (1993)

Miyake Y、Miyake K 和 Shiroyama N.：“无晶状体黄斑囊样水肿与局灶性黄斑视网膜电图的分类。”

Miyake Y, Awaya S et al: "Hyperbaric oxygen and acetazolamide imporve visual acuity in cystoid macular edema with different mechanisms." Arch Ophethalmol. 111. 1605-1606 (1993)

Miyake Y、Awaya S 等人：“高压氧和乙酰唑胺通过不同的机制改善黄斑囊样水肿的视力。”

Miyake Y, Shiroyama N, Ota I, and Horiguchi M.: "Focal macular electroretinogram in X-linked congenital retinoschisis." Invest Ophthalmol Vis Sci. 34. 512-515 (1993)

Miyake Y、Shiroyama N、Ota I 和 Horiguchi M.：“X 连锁先天性视网膜劈裂中的局灶性黄斑视网膜电图”。