Objective visual functions in macular diseases

黄斑疾病的客观视觉功能

• 批准号: 62480362
• 负责人: MIYAKE Yozo
• 金额: $ 4.29万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480362/
• 关键词: focal macular ERG; oscillatory potentials; foveal cone densitometry; layer-by-layer; objective methods; central serous chorioretinopathy; selective reduction of oscillatory potentials; 律動様小波; 経年変化; 糖尿病性黄斑症; Retinal Densitometry; 錐体視物質; 局所ERG /

The studies of focal macular ERG have been made with special reference to its suitable recording condition and functional properties by using fundus monitoring system in human. By improving the signal to noise ratio, we successfully recorded the oscillatory potentials (OPs) in addition to a-wave, b-wave and, offresponse in human macular region. The distribution of OPs in relation to those in a-wave and b-wave was studied. The amplitude of a-wave, b-wave and OPs of the upper macular region was significantly larger than that of lower macular region.The changes of amplitude in response to the spot size and ring stimuli indicated that the distribution of OPs is relatively sparse in the fovea, and it becomes relatively more dense than those of a-wave and b-wave from the fovea toward the parafovea, and even more strikingly toward the perifovea. There was no statistical difference of amplitude in both a-wave and b-wave between temporal and nasal macula. However, the amplitude of OPs in tempor … More al macula was significantly larger than that in nasal macula. we studied several macular diseases with focal macular ERG in terms of a-wave, b-wave, off-responses and OPs. In some macular diseases, such as diabetic maculopathy, c)(stoid macular edema or convalescent stage of idiopathic central serous chorioretinopathy, the macular OPs were selectively reduced, leaving the a-wave and b-wave intact. The macular OPs can be a sensitive indicator to assess the macular function in several macular diseases.We built a prototype apparatus for foveal cone densitometry that combined a modified fundus camera, independent optic pathways, and a personal computer.Using a two-way density technique, the density and regeneration time of the foveal cone pigment can be measured objectively: Foveal cone densitometry may elucidate some aspects of macular pathology that cannot be ascertained by psychophysical or electrophysiological techniques.By combining these two methods, layer-by-layer analysis of macular diseases can be performed by objectively measured visual functions. Less

利用人眼眼底监测系统对黄斑局灶性肌电图进行了研究，重点探讨了其适宜的记录条件和功能特性。通过提高信噪比，我们成功地记录了人类黄斑区除a波、b波和off反应外的振荡电位（OPs）。研究了a波和b波中OPs的分布。黄斑上区a波、b波和OPs的振幅明显大于下区。振幅随光斑大小和圆环刺激的变化表明，OPs在中央凹内的分布相对稀疏，从中央凹向副中央凹的分布比a波和b波的分布更为密集，向中心凹周围的分布更为明显。颞部黄斑与鼻部黄斑a波、b波振幅差异无统计学意义。而颞部黄斑的OPs振幅明显大于鼻腔黄斑。我们从a波、b波、无反应和OPs方面研究了几种黄斑病变伴局灶性黄斑ERG。在某些黄斑疾病中，如糖尿病性黄斑病变(c)样黄斑水肿或特发性中枢性浆液性脉络膜视网膜病变恢复期，黄斑OPs选择性降低，a波和b波保持完整。黄斑OPs是几种黄斑疾病中评价黄斑功能的敏感指标。我们建立了一个中央凹锥体密度测量的原型装置，它结合了一个改进的眼底相机、独立的光学通路和一台个人计算机。使用双向密度技术，可以客观地测量中央凹锥色素的密度和再生时间：中央凹锥密度测量可以阐明一些无法通过心理物理或电生理技术确定的黄斑病理方面。结合这两种方法，可以通过客观测量的视觉功能对黄斑疾病进行逐层分析。少

项目成果

Miyake Y: "Bull,s-eye maculopathy and negative electroretinogram." Retina. 9. 210-215 (1989)

Miyake Y：“牛眼黄斑病和阴性视网膜电图。”

Miyake Y: "Layer-by-layer analysis of macular diseases with objectively measured visual functions." Jpn J Ophthalmol. (1990)

Miyake Y：“通过客观测量的视觉功能对黄斑疾病进行逐层分析。”

Miyake Y: "Bull's-eye maculopathy and negative electroretinogram." Retina. 9. 210-215 (1989)

Miyake Y：“牛眼黄斑病和阴性视网膜电图。”

Miyake,Y.;Shiroyama,N.;Ota.I.;Horiguchi M.: Investigative of Ophthalmology and Visual Science. 29. 1631-1636 (1988)

Miyake，Y.；Shiroyama，N.；Ota.I.；Horiguchi M.：眼科和视觉科学的调查。

Miyake Y: "Macular oscillatory potentials in human" Doc Ophthalmol. (1990)

Miyake Y：“人类黄斑振荡电位”Doc Ophasemol。