Layer-by-layer evaluation of function and morphology in macular diseases.

黄斑疾病功能和形态的逐层评估。

• 批准号: 11470363
• 负责人: MIYAKE Yozo
• 金额: $ 10.56万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470363/
• 关键词: focal macular ERG; OCT; visual function; morphology; diabetic; macular edema; inner limitting membrane; macular hole; 黄斑部局所ERG; 糖尿病黄斑浮腫; 加齢黄斑変性; 硝子体黄斑けん引症候群; 中心性漿液性脈絡網膜症

We investigated the vusual function and morphology by analysing each component of focal macular ERG (electroretinogram) and OCT (optical coherent tomography) in patients with variable macular diseases before and after macular surgery.In diabetic macula edema, many patients showed good recovery of morphology evaluated by OCT after vitrectomy, however, only limitted patients showed good recovery of focal macular ERG.This results suggest that the functional recovery shown by focal macular ERG may delay significantly as compared with the recovery of macular morphology.The inner limitting membrane around the macular area may be removed to relax the retina during macular hole surgery, however little is known about the side-effect of this procedure. We compared the group with removing the inner limitting membrane (Group A) and group without removing it (Group B) in idiopathic macular hole patients. We found that the recovery of ERG b-wave significantly delayed in Group A.Above results indicate that the evaluation of macular condition using functional techinique (focal macular ERG) and morphological technique (OCT) can provide useful informations in terms of the pathophysiology before and after macular surgery.

通过对不同黄斑病变患者黄斑手术前后黄斑ERG和光学相干断层扫描(OCT)各成分的分析，了解黄斑病变患者手术前后的功能和形态变化。在糖尿病黄斑水肿患者中，玻璃体手术后OCT评估的许多患者的形态恢复良好，但只有有局限性的患者表现出良好的黄斑ERG恢复。这一结果表明，与黄斑形态的恢复相比，黄斑ERG显示的功能恢复可能显著延迟。黄斑裂孔手术中可以去除黄斑区周围的内限制膜以放松视网膜，但这种方法的副作用尚不清楚。对特发性黄斑裂孔患者行内界膜摘除组(A组)和不摘除内界膜组(B组)进行比较。我们发现A组ERGb波的恢复明显延迟。这一结果表明，用功能技术(局部黄斑ERG)和形态技术(OCT)评估黄斑状况可以为黄斑手术前后的病理生理提供有用的信息。

项目成果

Piao CH et al: "Multifocal ERG in occult macular dystrophy"Invest Ophthalmol.Vis Sci. 41. 513-517 (2000)

Piao CH 等人：“隐匿性黄斑营养不良中的多焦 ERG”Invest Ophthalmol.Vis Sci。

Asami T et al: "Vitreoretinal traction maculopathy caused by retinal diseases."Am J Ophthalmol. 131. 134-136 (2001)

Asami T 等人：“由视网膜疾病引起的玻璃体视网膜牵拉性黄斑病变。”Am J Ophamol。

Miyake Y, Terasaki H: "Golden tapetal-like fundus reflex and posterior hyaloid in a patient with x-lined juvenile retinoschisis."Retina. 19. 84-86 (1999)

Miyake Y，Terasaki H：“X线青少年视网膜劈裂患者的金色绒毡状眼底反射和后玻璃体。”视网膜。

三宅養三: "硝子体手術に伴う視機能低下"眼科臨床医報. 93. 1395-1397 (1999)

Yozo Miyake：“与玻璃体切除术相关的视觉功能恶化”眼科临床医生通报 93. 1395-1397 (1999)。

Shimazu K, Miyake Y, et al.: "Retinal ganglion cell response properted in the transcorneol electrically evoked response of visual system."Vision Res.. 39. 2251-2260 (1999)

Shimazu K、Miyake Y 等人：“视网膜神经节细胞反应在视觉系统的跨角电诱发反应中得到体现。”Vision Res.. 39. 2251-2260 (1999)