Basic and clinical study of multifocal ERG

多焦ERG的基础与临床研究

• 批准号: 08457462
• 负责人: MIYAKE Yozo
• 金额: $ 4.67万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457462/
• 关键词: multifocal ERG; macular ERG; television monitor; first order; second order; occult macular dystrophy; cone dystrophy; retinitis pigmentosa; 糖尿病黄斑症; 網膜内層障害; m-sequence; クラッシュERG; ON,OFF反応; グルタメートアナログ; occult macular dystropliy

We studied the multifocal electroretinogram (ERG) in terms of the recording methods, the origin of the response, and the usefulness and limitation in evaluating clinical diseases. We found that some patients with poor visual acuity and central scotoma may show poor fixation during recording, which may cause a significant artifact. In such case, we proved that the fundus monitor is essential through the infrared television fundus camera during recording.In comparison with the conventional focal macular ERG,the a-wave in multifocal ERG was proved to have the same origin to that of conventional multifocal ERG.We found a macular dystrophy with a new clinical entity where the ophthalmoscopical macular finding is normal and only the multifocal ERg shows enormous abnormality. We termed "Occult Macular Dystrophy" for this disorder.

本文对多焦视网膜电图（ERG）的记录方法、反应来源、临床诊断价值及局限性进行了研究。我们发现，一些视力差和中心暗点的患者可能在记录过程中表现出不良的注视，这可能会导致明显的伪影。在这种情况下，我们通过红外电视眼底照相机记录证实了眼底监测的必要性，与常规的焦点黄斑ERG相比，多焦点ERG的a波与常规的多焦点ERG的a波具有相同的起源，我们发现了一种新的黄斑营养不良的临床实体，眼底镜检查黄斑发现是正常的，只有多焦点ERG显示出巨大的异常。我们将这种疾病称为“隐性黄斑营养不良”。

项目成果

Terasaki.H.Hirose H.Miyake.Y.: "S-cone Pathway sensitivity in diabetes measures with threshold versus intensity curves on flashed backgrounds." Invest Opthalmol Vis Sci. 37. 680-684 (1996)

Terasaki.H.Hirose H.Miyake.Y.：“糖尿病中的 S 锥通路敏感性通过闪光背景上的阈值与强度曲线进行测量。”

Terasaki H,Hirose H,Miyake Y.: "S-cone pathway sensitivity in diabetes measures with threshold versus intensity curves on flashed backgrounds" Invest Ophthalmol Vis Sci. 37. 680-684 (1996)

Terasaki H、Hirose H、Miyake Y.：“糖尿病中的 S 锥通路敏感性测量，在闪光背景下使用阈值与强度曲线进行测量”Invest Ophasemol Vis Sci。

Kondo M,Miyake Y,Horiguchi M,Suzuki S,Tanikawa A.: "Recording multifocal electroretinogram with fundus monitoring" Invest Ophthalmol Vis Sci. 38. 1049-1053 (1997)

Kondo M、Miyake Y、Horiguchi M、Suzuki S、Tanikawa A.：“通过眼底监测记录多焦视网膜电图”Invest Ophasemol Vis Sci。

Miyake Y,Horiguchi M,Tomita N,Kondo M,Tanikawa A,Takahashi H,Suzuki S,Terasaki H.: "Occult macular dystrophy." Amer J Ophthalmol. 122. 644-653 (1996)

Miyake Y，Horiguchi M，Tomita N，Kondo M，Tanikawa A，Takahashi H，Suzuki S，Terasaki H.：“隐匿性黄斑营养不良。”

Kondo M,Miyake Y et al: "Recording multifocal electroretinogram with fundus monitoring" Invest Ophthalmol Vis Sci. (in press)

Kondo M、Miyake Y 等人：“通过眼底监测记录多焦视网膜电图”Invest Ophthalmol Vis Sci。