Basic and clinical studies on HTLV-I uveitis

HTLV-I葡萄膜炎的基础与临床研究

• 批准号: 04454448
• 负责人: MOCHIZUKI Manabu
• 金额: $ 4.16万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454448/
• 关键词: HTLV-I; Uveitis; Vitreous opacities; Seroepidemiology; Polymerase chain reaction

This study was aimed at determining the association of human T lymphotropic virus type 1 (HTLV-I) infection with certain type of uveitis that was classified as idiopathic on the basis of conventional diagnostic criteria. The seroprevalence of HTLV-I in idiopathic uveitis was significantly higher than that in two control groups, i. e. uveitis with defined etiology and non-uveitic ocular diseases. The odds ratio of idiopathic uveitis for HTLV-I infection was estimated to be 11.0 at younger aged group (20-49 years old), while being 2.0 at older aged group (50<) in an HTLV-I endemic area. A similar observation was recorded even in an HTLV-I less endemic area. Clinical features of the patients were characterized by intermediate uveitis consisting of moderate vitreous opacities, mild iritis and retinal vasculitis. Proviral DNA of HTLV-I was detected from inflammatory cells of the anterior chamber in all tested patients by polymerase chain reaction, suggesting the presence of HTLV-I infected cells in uveitic eyes.

本研究旨在确定人类T淋巴细胞病毒1型（HTLV-I）感染与某些类型的葡萄膜炎，被归类为特发性的基础上，传统的诊断标准的关联。特发性葡萄膜炎组HTLV-Ⅰ的阳性率明显高于两个对照组，即正常对照组和特发性葡萄膜炎组。e.具有明确病因的葡萄膜炎和非葡萄膜炎性眼部疾病。在HTLV-Ⅰ型流行区，特发性葡萄膜炎与HTLV-Ⅰ型感染的比值比在年轻组（20-49岁）为11.0，而在老年组（50岁以下）为2.0。即使在HTLV-I流行程度较低的地区也记录了类似的观察结果。患者的临床特征为中间葡萄膜炎，包括中度玻璃体混浊，轻度虹膜炎和视网膜血管炎。通过聚合酶链反应从所有受试患者的前房炎性细胞中检测到HTLV-I的前病毒DNA，表明葡萄膜炎眼中存在HTLV-I感染细胞。

项目成果

山口 一成: "HTLV-Iぶどう膜炎" 血液・腫瘍科. 25. 405-409 (1992)

Kazunari Yamaguchi：“HTLV-I 葡萄膜炎”血液学和肿瘤学系 25. 405-409 (1992)。

望月 學: "HTLV-Iとぶどう膜炎" 病理と臨床. 11. 204-210 (1993)

Manabu Mochizuki：“HTLV-I 和葡萄膜炎”病理学和临床实践 11. 204-210 (1993)。

Koichi Yoshimura: "Uveitis in Human T-lymphotropic Virus Type I (HTLV-I) Carriers-2. An analysis of clinical features -." Journal of Japanese Ophthalmological Society. 97. 733-740 (1993)

Koichi Yoshimura：“人类 T 淋巴细胞病毒 I 型 (HTLV-I) 携带者的葡萄膜炎 - 2。临床特征分析 -”。

望月 學: "HTLV-Iぶどう膜炎" Medical Immunology. 23. 589-595 (1992)

Manabu Mochizuki：“HTLV-I 葡萄膜炎”医学免疫学 23. 589-595 (1992)。

望月 學: "HTLV-Iとぶどう膜炎" 実験医学. 11. 105-110 (1993)

Manabu Mochizuki：“HTLV-I 和葡萄膜炎”实验医学。11. 105-110 (1993)。