Personal Made Immuno-therapy for Uveitis Using Regulatory T Cells
Personal Made Immuno-therapy for Uveitis Using Regulatory T Cells
批准号:
23659807
负责人:
MOCHIZUKI Manabu
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Regulatory T cells (Treg) induced by retinal pigment epithelial cells strongly suppressed proliferation of active T cells and production of inflammatory cytokines by T cells. Furthermore, removing non-suppressive fraction of Treg exhibited much more intense suppressive activities. The suppressive fraction of Treg was capable of suppressing experimental autoimmune uveitis in mice. In human, Treg and suppressive fraction of Treg were induced similarly, but using pre-stimulation by TGF-b.These results indicate that Treg (or suppressive fraction of Treg) can be used for the treatment of non-infectious uveitis in human.
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Immunosuppressive properties of retinal pigment epithelial (RPE)-induced regulatory T cells
视网膜色素上皮 (RPE) 诱导的调节性 T 细胞的免疫抑制特性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Jiying Wang, Kyoko Ohno-Matsui, Ikuo Morita, Mochizuki M]
通讯作者:
Mochizuki M
DOI:
10.1016/j.exer.2011.11.002
发表时间:
2012-01-01
期刊:
EXPERIMENTAL EYE RESEARCH
影响因子:
3.4
作者:
[Kawazoe, Yuko, Sugita, Sunao, Mochizuki, Manabu]
通讯作者:
Mochizuki, Manabu
制御性T細胞を用いたぶどう膜炎免疫治療の可能性.
使用调节性 T 细胞对葡萄膜炎进行免疫治疗的可能性。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[今井彩乃, 杉田 直, 山田由季子, 川添裕子, 堀江真太郎, 高瀬 博, 望月 學.]
通讯作者:
望月 學.
Immunosuppressive properties of retinal pigment epithelial (RPE)-induced regulatory T cells.
视网膜色素上皮 (RPE) 诱导的调节性 T 细胞的免疫抑制特性。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Zhang Q, Kaga K, Hayashi A, Mochizuki M]
通讯作者:
Mochizuki M
ベーチェット病に対するインフリキシマブ長期投与成績の検討.
检查英夫利昔单抗治疗白塞氏病的长期给药结果。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Furuya, T, 川添裕子]
通讯作者:
川添裕子
共 19 条
Molecular mechanisms of natural immunity in the eye
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批准号:19390440
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2007
-
负责人:MOCHIZUKI Manabu
-
依托单位:
Establishment of Animal Model and the effect of hyaluronan administration for the cultured chondrocytes transplantation
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批准号:14560261
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:MOCHIZUKI Manabu
-
依托单位:
Analysis of gene and protein expression on infiltrating lymphocytes
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批准号:14370555
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
-
财政年份:2002
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负责人:MOCHIZUKI Manabu
-
依托单位:
Study on the treatment of osteoarthritis using sheep model
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批准号:10839005
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1998
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负责人:MOCHIZUKI Manabu
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依托单位:
Immunological and Molecular Biological Research on Local Defense System of the Eye
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批准号:10470368
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1998
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负责人:MOCHIZUKI Manabu
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依托单位:
Clinical and basic research on the pathogenic mechanisms of HTLV-I uveitis
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批准号:06454501
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.67万
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财政年份:1994
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负责人:MOCHIZUKI Manabu
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依托单位:
Basic and clinical studies on HTLV-I uveitis
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批准号:04454448
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1992
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负责人:MOCHIZUKI Manabu
-
依托单位:
Genetic control of experimental autoimune uveitis in the mouse
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批准号:02454401
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1990
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负责人:MOCHIZUKI Manabu
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依托单位:
海外基金