Tumor associated gene in chromosomal translocation in acute leukemia

40例急性淋巴细胞白血病（t（1 ; 19）-ALL）患者中10例检测到E2 A-PBX 1嵌合体mRNA。20例t（1 ; 19）-ALL中2例在诊断时、4例在复发时和5例细胞系中4例p53改变。我们的结论是，p53改变与复发或进展。我们检测了99例恶性血液病患者的TAL 1基因，发现10例T-ALL患者存在TAL 1基因的异常。19 t（16 ; 21）急性髓系白血病（AML）患者均检测到TLS/FUS-ERG嵌合体mRNA，其中18例死亡。结论：t（16 ; 21）-AML患者预后差，应在首次缓解期行造血干细胞移植治疗。对11 q23异常的白血病进行MLL基因分析。我们发现MLL重排的婴儿预后不良。我们还发现了MLL基因的3个伴侣基因AF-5 α、CBP和p300基因。我们研究了这些基因在白血病发展中的作用。

E2A-PBX1 chimeric mRNA,which was reported in t (1 ; 19)-acute lymphoblastic leukemia (ALL), was found in 10 of 40 ALL patients. p53 alteration was found in 2 of 20t (1 ; 19)-ALL at diagnosis, 4 of 4 at relapse and 4 of 5 cell lines. We conclude that p53 alteration is associated with relapse or progression. We examined TAL1 alteration in 99 hematological maligmacines and found the alteration in 10 T-ALL patients. Theses patients had similar immunophonotype, normal karyotype, good prognosis, resulting in a subset of T-ALL.TLS/FUS-ERG chimeric mRNA was found in all the 19t (16 ; 21)-acute myeloid leukemia (AML), 18 of whom died. We concluded that t (16 ; 21)-AML patient has a poor prognosis and should be treated by stem cell transplantation in the first remission. MLL gene analysis was preformed on leukemia with 11q23 abnormalities. We found that infant with MLL rearrangements was a poor prognosis. We also found 3 partner genes of MLL gene, AF-5alpha, CBP and p300 gene. We examined the role of these genes in the development of leukemia.