Tumor associated gene in chromosomal translocation in acute leukemia

T(1；19)急性淋巴细胞白血病(ALL)患者中有10例检测到E2a-Pbx1嵌合基因。2/20T(1；19)-ALL初诊时、4/4复发时和4/5细胞系中发现P53改变。我们得出结论，P53的改变与复发或进展有关。我们检测了99例恶性血液病患者的TAL1改变，发现10例T-ALL患者有这种改变。所有19T(16；21)急性髓系白血病(AML)患者免疫表型相似，核型正常，预后良好，均检测到TLS/FUS-ERG嵌合mRNA，其中18例死亡。我们认为t(16；21)-AML患者预后较差，首次缓解时应进行干细胞移植治疗。对伴有11q23异常的白血病患者进行MLL基因分析。我们发现MLL重排的婴儿预后很差。我们还发现了MLL基因的3个配对基因，即AF-5α、CBP和p300基因。我们研究了这些基因在白血病发生发展中的作用。

E2A-PBX1 chimeric mRNA,which was reported in t (1 ; 19)-acute lymphoblastic leukemia (ALL), was found in 10 of 40 ALL patients. p53 alteration was found in 2 of 20t (1 ; 19)-ALL at diagnosis, 4 of 4 at relapse and 4 of 5 cell lines. We conclude that p53 alteration is associated with relapse or progression. We examined TAL1 alteration in 99 hematological maligmacines and found the alteration in 10 T-ALL patients. Theses patients had similar immunophonotype, normal karyotype, good prognosis, resulting in a subset of T-ALL.TLS/FUS-ERG chimeric mRNA was found in all the 19t (16 ; 21)-acute myeloid leukemia (AML), 18 of whom died. We concluded that t (16 ; 21)-AML patient has a poor prognosis and should be treated by stem cell transplantation in the first remission. MLL gene analysis was preformed on leukemia with 11q23 abnormalities. We found that infant with MLL rearrangements was a poor prognosis. We also found 3 partner genes of MLL gene, AF-5alpha, CBP and p300 gene. We examined the role of these genes in the development of leukemia.