Tumor associated gene in chromosomal translocation in acute leukemia

E2A-PBX1嵌合mRNA在t(1; 19)-急性淋巴细胞白血病（ALL）中有报道，在40例ALL患者中有10例发现。诊断时20t (1; 19)-ALL中有2例发现p53改变，复发时4例发现p53改变，5例细胞系中4例发现p53改变。我们得出结论，p53的改变与复发或进展有关。我们在99例血液学恶性机器中检测了TAL1的改变，并在10例T-ALL患者中发现了TAL1的改变。这些患者免疫表型相似，核型正常，预后良好，形成T-ALL亚群。19例（16例；21例）急性髓性白血病（AML）患者中均发现TLS/FUS-ERG嵌合mRNA，其中18例死亡。我们认为t (16; 21)-AML患者预后较差，应在首次缓解时进行干细胞移植治疗。对11q23异常的白血病进行MLL基因分析。我们发现有MLL重排的婴儿预后较差。我们还发现了MLL基因的3个伴侣基因，AF-5alpha、CBP和p300基因。我们研究了这些基因在白血病发展中的作用。

E2A-PBX1 chimeric mRNA,which was reported in t (1 ; 19)-acute lymphoblastic leukemia (ALL), was found in 10 of 40 ALL patients. p53 alteration was found in 2 of 20t (1 ; 19)-ALL at diagnosis, 4 of 4 at relapse and 4 of 5 cell lines. We conclude that p53 alteration is associated with relapse or progression. We examined TAL1 alteration in 99 hematological maligmacines and found the alteration in 10 T-ALL patients. Theses patients had similar immunophonotype, normal karyotype, good prognosis, resulting in a subset of T-ALL.TLS/FUS-ERG chimeric mRNA was found in all the 19t (16 ; 21)-acute myeloid leukemia (AML), 18 of whom died. We concluded that t (16 ; 21)-AML patient has a poor prognosis and should be treated by stem cell transplantation in the first remission. MLL gene analysis was preformed on leukemia with 11q23 abnormalities. We found that infant with MLL rearrangements was a poor prognosis. We also found 3 partner genes of MLL gene, AF-5alpha, CBP and p300 gene. We examined the role of these genes in the development of leukemia.