Effectiveness and safety of intrauterine pacing for fetal arrhythmia (comple atrioventricular block) - an experimental study

宫内起搏治疗胎儿心律失常（完全性房室传导阻滞）的有效性和安全性 - 一项实验研究

• 批准号: 04807069
• 负责人: SHIRAISHI Hirohiko
• 金额: $ 1.34万
• 依托单位: Jichi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04807069/
• 关键词: Fetal lamb; Sheep; Pacemaker; Atrial Flutter; Complete AV block; Fetal hydrops; Fetus; 完全房〓ブロック; 人工ペースメーカー; 発作性上室性頻拍; 不整脈

In 1992, we have investigated intrauterine transvenous ventricular pacing in fetal lamb. The pacing lead was advanced through the internal jugular vein and the tricuspid valve. The fetal right ventricle was paced by a pacemaker at a rate of 200/min. The right ventricular output decreased from 107 ml/kg/min to 78 ml/kg/min while paced. Although the right ventricular output decreased when paced at 200/min, this method might be useful when there is a complete heart block and congestive heart failure.In 1993, we have investigated intrauterine acute atrial pacing in fetal lamb. The pacing lead was sutured on the right atrium through the right thoracotomy. The right atrium was paced at 200,300,350, and 400/min. The right ventricular output decreased when paced at more than 200/min. Using this atrial tachy arrhythmia model, we can estimate the human fetal circulation with tachy arrhythmia.In 1994, we have investigated intrauterine chronic atrial pacing in fetal lamb. In this preliminary study, the fetal hydrops was observed when chronically paced at 300/min.

1992年，我们对胎羊进行了宫内经静脉心室起搏的研究。通过颈内静脉和三尖瓣推进起搏电极导线。用起搏器以200/min的速率起搏胎儿右心室。起搏时右心室输出量从107 ml/kg/min降至78 ml/kg/min。虽然以200/min起搏时右心室输出量减少，但当存在完全性心脏传导阻滞和充血性心力衰竭时，这种方法可能是有用的。通过右胸切口将起搏电极导线缝合在右心房上。用200、300、350、400次/min起搏右心房，超过200次/min起搏右心室输出量减少，用此快速房性心律失常模型可估计胎儿快速房性心律失常时的循环。在这项初步研究中，当以300/min的速度慢性起搏时，观察到胎儿水肿。

项目成果

Yutaka Kikuchi,Hirohiko SHIRAISHI: "Cardiac pacing in fetal lambs:intraterine transverous cardiac pacing for fetal complete heart block" PACE. 18(3月号). (1995)

Yutaka Kikuchi、Hirohiko SHIRAISHI：“胎儿羔羊的心脏起搏：胎儿完全性心脏传导阻滞的宫内经皮心脏起搏”PACE 18（1995 年 3 月）。

Yutaka KIKUCHI: "Cardiac pacing in fetal lambs : intrauterine transvenous cardiac pacing for complete heart block." PACE. 18. 417-423 (1995)

Yutaka KIKUCHI：“胎儿羔羊的心脏起搏：宫内经静脉心脏起搏实现完全心脏传导阻滞。”

菊地豊: "Cardiac pacing in fetal lamps : intrnuterine tromsvenous cardiac pacing for complete heart block." PACE. 18. 417-423 (1995)

Yutaka Kikuchi：“胎儿灯中的心脏起搏：子宫内静脉心脏起搏用于完全心脏传导阻滞。”18. 417-423 (1995)。