Effectiveness and safety of intrauterine pacing for fetal arrhythmia (comple atrioventricular block) - an experimental study

1992年，我们对胎羊的宫内经静脉心室起搏进行了研究。起搏导线通过颈内静脉和三尖瓣推进。胎儿右心室由起搏器以200次/分钟的速率起搏。右心室输出量从107 ml/kg/min降至78 ml/kg/min。虽然当起搏速度为200/min时右心室输出量下降，但这种方法可能对有完全性心脏传导阻滞和充血性心力衰竭的患者有用。1993年，我们研究了胎羊的宫内急性心房起搏。起搏导线通过右开胸缝合在右心房上。右心房起搏分别为200,300,350和400/min。当起搏超过200次/分时，右心室输出量下降。利用该心房速性心律失常模型，我们可以估计伴有心房速性心律失常的胎儿循环。1994年，我们研究了胎儿羔羊的子宫内慢性心房起搏。在这项初步研究中，当慢速300/min时观察到胎儿水肿。

In 1992, we have investigated intrauterine transvenous ventricular pacing in fetal lamb. The pacing lead was advanced through the internal jugular vein and the tricuspid valve. The fetal right ventricle was paced by a pacemaker at a rate of 200/min. The right ventricular output decreased from 107 ml/kg/min to 78 ml/kg/min while paced. Although the right ventricular output decreased when paced at 200/min, this method might be useful when there is a complete heart block and congestive heart failure.In 1993, we have investigated intrauterine acute atrial pacing in fetal lamb. The pacing lead was sutured on the right atrium through the right thoracotomy. The right atrium was paced at 200,300,350, and 400/min. The right ventricular output decreased when paced at more than 200/min. Using this atrial tachy arrhythmia model, we can estimate the human fetal circulation with tachy arrhythmia.In 1994, we have investigated intrauterine chronic atrial pacing in fetal lamb. In this preliminary study, the fetal hydrops was observed when chronically paced at 300/min.