Separation and Purification of Polyunsaturated Fatty Acids by SolventExtraction and Liquid Membrane Methods Using Silver Salt.

使用银盐通过溶剂萃取和液膜方法分离和纯化多不饱和脂肪酸。

• 批准号: 05453101
• 负责人: TERAMOTO Masaaki
• 金额: $ 2.37万
• 依托单位: Kyoto Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05453101/
• 关键词: Polyunsaturated fatty acid; Eicoapentaenoic acid; Docosahexaenoic acid; Silver nitrate; Liquid membrane; Carrier transport; Extraction; Uphill transport; イオン交換膜

Extraction equilibria in the extraction of ethyl esters of PUFA (PUFA-Et) such as EPA-Et and DHA-Et with silver nitrate solutions were investigated. The results suggest that PUFA-Et is extracted as the complex (PUFA-Et・nAg) ^<n+> in the aqueous phase (n : number of C=C in PUFA). The solvent effect on the distribution ratio was interpreted by the UNIFAC equation. Addition of alcohol to the aqueous phase incraesed the distribution ratio remarkably.Experiments on the extraction of EPA-Et and DHA-Et contained in bonito oil ethyl ester (bonito oil-Et) with aqueous silver nitrate solutions were performed using a countercurrent vibromixer with a feed inlet in the middle of the column. The results were interpreted by the model calculation.PUFA-Ets in n-dodecane were successfully transported to m-xylene phase against their concentration gradidnts through supported liquid membranes containing silver nitrate as a carrier.A circulating liquid membrane was proposed where a silver nitrate solution was circulated between a feed phase and the receiving phase vessels. PUFA-Ets were transported against their concentration gradients from the feed vessel to the receiving vessel which was kept at higher temperature than the feed vessel. These are new types of uphill transport utiulizing the solvent ] and the temperature effects on the distribution ratios.

本文研究了银溶液萃取多不饱和脂肪酸乙酯（PUFA-Et）如EPA-Et和DHA-Et的萃取平衡。结果表明，PUFA-Et在水相中以（PUFA-Et·nAg）^<n+>（n为PUFA中C=C的个数）的形式被萃取。溶剂效应对分配比的影响可用THAAC方程解释。用银银水溶液萃取鲣鱼油乙酯中的EPA-Et和DHA-Et。结果表明，以硝酸银为载体的支撑液膜能将正十二烷中的PUFA-Ets以浓度梯度转移到间二甲苯相中，并提出了一种循环液膜，即硝酸银溶液在进料相和接收相容器之间循环。PUFA-Ets逆着它们的浓度梯度从进料容器输送到保持在比进料容器更高的温度下的接收容器。这些是利用溶剂和温度对分配比的影响的新型上坡运输。

项目成果

寺本正明(共著): "膜分離プロセスの理論と計算" 酒井清孝, 496 (1993)

Masaaki Teramoto（合著者）：《膜分离过程的理论与计算》Kiyotaka Sakai，496（1993）

Masaaki Teramoto: "Permeation Rate of Polyunsaturated Fatty Acids through Liquid Membranes" Proceedings of 26th Autumn Meetings of the Society of Chemical Engineers of Japan. vol.1. 22 (1993)

Masaaki Teramoto：“多不饱和脂肪酸通过液膜的渗透率”日本化学工程师学会第 26 届秋季会议论文集。

寺本正明: "Facilitated Uphill Transport of Polyunsaturated Fatty Acids by Bulk,Supported and Flowing Liquid Membranes." Abstract of ICOM'93. 8.17-8.17 (1993)

Masaaki Teramoto：“通过散装、支撑和流动液体膜促进多不饱和脂肪酸的上坡运输。”ICOM93 8.17-8.17 摘要（1993 年）。

寺本正明: "Separation of Polyunsaturated Fatty Acids by Solvent Extraction and Liquid Membrane Using Silver Nitrate Solution." Solvent Extraction 1993,Solvent Extraction in the Process Industry. 2. 909-916 (1993)

Masaaki Teramoto：“使用硝酸银溶液通过溶剂萃取和液膜分离多不饱和脂肪酸。”溶剂萃取 1993，过程工业中的溶剂萃取 2. 909-916 (1993)。

Masaaki Teramoto: "Facilitated Uphill Transport oh Eicosapentaenoic Acid Ethyl Ester through Bulk and Supported Liquid Membranes Containing Silver Nitrate as carrier : a New Type of Uphill Transport" J.Membrane Science. 91,1&2. 209-213 (1994)

Masaaki Teramoto：“通过含有硝酸银作为载体的散装和支撑液体膜促进二十碳五烯酸乙酯的上坡运输：一种新型的上坡运输”J.Membrane Science。