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Role of Sympatho-vagal Regulation on Ventricular Arterial Coupling

交感迷走神经调节对心室动脉耦合的作用

基本信息

批准号：
05454281
负责人：
SUNAGAWA Kenji
金额：
$ 4.22万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454281/
关键词：
ventricular efficiency end-systolic elastance effective arterial elastance baroreflex sympathetic nervous system vagal system transfer function white noise technique 交感神経

项目摘要

Since the heart continues to pump blood throughout the life time, the amount of energy required to support the heart becomes enormous. Although many investigators demonstrated that ventricular coupling with the arterial system is energeticaly efficient, it is not known the role of the autonomic nervous system in the ventricullar arterial coupling. The purpose of this investigation was to elucidate the mcchanism by which the sympathetic system and vagal system affect the ventricular arterial coupling.In the first year, we investigated how the sympathetic system affects ventricular-arterial coupling. In anesthetized, vagotomized dogs, we isolated the carotid sinuses and altered intrasinus pressurc (csp) randomly while measuring end-systolic ventricular elastance (Ees) and effective arterial elastance (Ea). We estimated transfer functions from CSP to Ees and Ea. The transfer function from CSP to Ees was remarkably similar to that from CSP to Ea. This implies that whenever the baroreflex i … More s activated, both Ees and Ea change with a similar time course. Thus, the ratio of Ea/Ees, that is the determinant of efficiency of ventricular ejection, will remain unaltered irrespective of changes in CSP.Since Ea/Ees is set to a point where the efficiency is fairly optimum, this observation indicated that baroreflex adjusts blood pressure while maintaining efficiency of ventricular ejection.In the second year, we investigated how the vagal system affected ventricular arterial coupling. In anesthetized, sympathectomized rabbits, we electrically stimulated the cardiac vagal nerve while measuring Ees and Ea. We then estimated the transfer functions from vagal stimulation to Ees and to Ea. The transfer function from the vagal stimulation to Ees strikingly resembled that from the vagal stimulation to Ea. This implied that the vagal regulation did not alter efficient coupling of the ventricle with the arterial system.We conclude that the autonomic regulation of ventricular arterial coupling takes place so that efficient ventricular ejection is maintained. Less

由于心脏在整个生命周期中持续泵血，支持心脏所需的能量变得巨大。尽管许多研究人员证明了脑室与动脉系统的偶联在能量上是有效的，但自主神经系统在脑室动脉偶联中的作用尚不清楚。本研究的目的是阐明交感系统和迷走神经系统影响室动脉偶联的机制。第一年，我们研究了交感系统如何影响室-动脉偶联。在麻醉、切断迷走神经的狗身上，我们分离颈动脉窦并随机改变窦内压(CSP)，同时测量收缩末期心室弹性(EES)和有效动脉弹性(EA)。我们估计了从CSP到EES和EA的传递函数。从CSP到EES的传递函数与从CSP到EA的传递函数非常相似。这意味着每当压力反射I…S激活越多，EES和EA的变化具有相似的时间进程。因此，Ea/Ees的比值，即决定心室射血效率的因素，将保持不变，而不管CSP的变化。由于Ea/Ees被设置为效率相当最佳的点，这一观察表明压力感受器反射在维持心室射血效率的同时调节血压。在第二年，我们研究了迷走神经系统如何影响心室动脉偶联。在麻醉、切断交感神经的兔身上，我们在测量EES和EA的同时，电刺激心脏迷走神经。然后我们估计了从迷走神经刺激到电刺激和电刺激的传递函数。从迷走神经刺激到EES的传递函数与从迷走神经刺激到电针的传递函数非常相似。这表明迷走神经的调节并没有改变脑室和动脉系统的有效偶联。我们得出结论，心室动脉偶联的自主神经调节发生了，从而维持了有效的心室射血。较少