Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury

开发仿生压力反射系统克服颈髓损伤患者动脉压失调的探索

• 批准号: 18100006
• 负责人: SUNAGAWA Kenji
• 金额: $ 70.47万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18100006/
• 关键词: バイオニック医学; 血圧制御; 脊髄損傷; 自動治療; 生体医工学

Central baroreflex failure in spinal cord injuries results in serious orthostatic hypotension. Even the latest medical science fails to provide a fundamental remedy for those patients. Since somatic inputs affect sympathetic activities, we examined if transcutaneous electrical stimulation can feedback control arterial pressure (bionic baroreflex system) in spinalized patients. We identified skin regions capable of increasing arterial pressure in response to electrical stimulation. We then determined the transfer function from the stimulation to arterial pressure responses and developed the bionic baroreflex system. The bionic baroreflex system fully prevented orthostatic hypotension in patients with spinal cord injuries.

脊髓损伤后中枢压力反射障碍导致严重的直立性低血压。即使是最新的医学科学也无法为这些患者提供根本的治疗方法。由于躯体输入影响交感神经活动，我们研究了经皮电刺激是否可以反馈控制脊髓损伤患者的动脉压（仿生压力反射系统）。我们确定了能够增加动脉压的皮肤区域，以响应电刺激。然后，我们确定了从刺激到动脉压力反应的传递函数，并开发了仿生压力反射系统。仿生压力反射系统完全预防脊髓损伤患者的直立性低血压。

项目成果

Inhibition of Tumor Necrosis Factor-α-Induced Interleukin-6 Expression by Telmisartan Through Cross-Talk of Peroxisome Proliferator-Activated Receptor-γ With Nuclear Factor κB and CCAAT/Enhancer- Binding Protein-β

• DOI: 10.1161/hypertensionaha.108.126656
• 发表时间: 2009-05-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Tian, Qingping;Miyazaki, Ryohei;Sunagawa, Kenji
• 通讯作者: Sunagawa, Kenji

Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Prevents Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice

纳米颗粒介导的单核细胞选择性递送匹伐他汀可预防 ApoE 缺陷小鼠中血管紧张素 II 诱导的腹主动脉瘤形成

• 发表时间: 2010
• 作者: Katsuki S;et al
• 通讯作者: et al

Endogenous Angiotensin-(1-7) Activity in the Rostral Ventrolateral Medulla Is Enhanced in Spontaneously Hypertensive Rats via Sympathetic Nerve Activity

通过交感神经活动增强自发性高血压大鼠延髓头端腹外侧区的内源性血管紧张素-(1-7) 活性

• 发表时间: 2010
• 作者: Nakagaki T;et al
• 通讯作者: et al

Telmisartan inhibits sympathetic nerve activity through the reduction of oxidative stress and release of GABA in RVLM of hypertensive rats.

替米沙坦通过减少高血压大鼠 RVLM 中的氧化应激和 GABA 释放来抑制交感神经活动。

• 发表时间: 2010
• 作者: Kishi T;Hirooka Y;Sunagawa K.
• 通讯作者: Sunagawa K.

The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure.

大脑 Sigma-1 受体的减少导致心力衰竭时交感神经过度活跃。

• 发表时间: 2009
• 作者: Ito K;Hirooka Y;Sunagawa K.
• 通讯作者: Sunagawa K.