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Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury

Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury
开发仿生压力反射系统克服颈髓损伤患者动脉压失调的探索
批准号：
18100006
负责人：
SUNAGAWA Kenji
金额：
$70.47万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (S)
财政年份：
2006
资助国家：
日本
项目状态：
已结题
起止时间：
2006 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18100006/
关键词：
バイオニック医学血圧制御脊髄損傷自動治療生体医工学

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中文摘要
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英文摘要
Central baroreflex failure in spinal cord injuries results in serious orthostatic hypotension. Even the latest medical science fails to provide a fundamental remedy for those patients. Since somatic inputs affect sympathetic activities, we examined if transcutaneous electrical stimulation can feedback control arterial pressure (bionic baroreflex system) in spinalized patients. We identified skin regions capable of increasing arterial pressure in response to electrical stimulation. We then determined the transfer function from the stimulation to arterial pressure responses and developed the bionic baroreflex system. The bionic baroreflex system fully prevented orthostatic hypotension in patients with spinal cord injuries.
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会议论文
Inhibition of Tumor Necrosis Factor-α-Induced Interleukin-6 Expression by Telmisartan Through Cross-Talk of Peroxisome Proliferator-Activated Receptor-γ With Nuclear Factor κB and CCAAT/Enhancer- Binding Protein-β
DOI： 10.1161/hypertensionaha.108.126656
发表时间： 2009-05-01
期刊： HYPERTENSION
影响因子： 8.3
作者： [Tian, Qingping, Miyazaki, Ryohei, Sunagawa, Kenji]
通讯作者： Sunagawa, Kenji
Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Prevents Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice
纳米颗粒介导的单核细胞选择性递送匹伐他汀可预防 ApoE 缺陷小鼠中血管紧张素 II 诱导的腹主动脉瘤形成
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Katsuki S, et al]
通讯作者： et al
Endogenous Angiotensin-(1-7) Activity in the Rostral Ventrolateral Medulla Is Enhanced in Spontaneously Hypertensive Rats via Sympathetic Nerve Activity
通过交感神经活动增强自发性高血压大鼠延髓头端腹外侧区的内源性血管紧张素-(1-7) 活性
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Nakagaki T, et al]
通讯作者： et al
Telmisartan inhibits sympathetic nerve activity through the reduction of oxidative stress and release of GABA in RVLM of hypertensive rats.
替米沙坦通过减少高血压大鼠 RVLM 中的氧化应激和 GABA 释放来抑制交感神经活动。
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Kishi T, Hirooka Y, Sunagawa K.]
通讯作者： Sunagawa K.
共 131 条
    Functional Analysis of Muscle Specific NAD/NADH Dehydrogenase, and Establishment as a Biomarker for Cardiac Dysfunction.
    • 批准号：
      25670392
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2013
    • 负责人：
      SUNAGAWA Kenji
    • 依托单位：
      Kyushu University
    The role of hypoxia response system in the development of cardiovascular and metabolic diseases
    • 批准号：
      23659421
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2012
    • 负责人：
      SUNAGAWA Kenji
    • 依托单位：
      Kyushu University
    Strategic Autonomic Nervous Control Using Artificial Brainstem to Cope With Obstinate Cardiovascular Diseases
    Development of Bionic Baroreflex System for Treatment of Orthostatic Hypotension due to Shy-Drager Syndrome
    海外基金