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Strategic Autonomic Nervous Control Using Artificial Brainstem to Cope With Obstinate Cardiovascular Diseases

使用人工脑干进行战略性自主神经控制来应对顽固性心血管疾病

基本信息

批准号：
15200040
负责人：
SUNAGAWA Kenji
金额：
$ 24.21万
依托单位：
KYUSHU UNIVERSITY (2004-2005)National Cardiovascular Center Research Institute (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

In this study we demonstrated that controlling the autonomic tone arbitrarily by using an electronic artificial brainstem reduced the mortality and inhibited cardiac remodeling in the ischemia-induced heart failure model. In the electronic therapy targeting the vagus, a combination of the electronic treatment with beta-adrenergic inhibition showed more significant improvement, suggesting that the vagal effects are different from the beta-adrenergic inhibition. In the electronic therapy targeting the arterial baroreflex afferent pathway, vagotomy reduced the improvement of survival rate after acute myocardial ischemia, suggesting the importance of the vagal efferent pathway. Next, we speculated that anti-inflammatory effects through the abdominal vagus might contribute to the improvement of heart failure, and performed the electronic therapy in animals with abdominal vagal transection. The results indicate that the abdominal vagi contribute to the improvement of hemodynamics but not to … More the improvement of survival after myocardial ischemia. In parallel with these therapeutic experiments, we identified the dynamic characteristics of baroreceptor transduction and developed a new identification method for the arterial baroreflex central function. These studies should provide a basis necessary for integration of the artificial brainstem into the biological systems.The above-mentioned bionic medicine using the artificial brainstem is a fusion of the state-of-the-art medicine and the cutting-edge engineering, and is unique in the medical history. Because the bionic medicine was able to improve the prognosis of heart failure via mechanisms different from ordinary pharmacological treatments of sympathetic inhibition, the present therapeutic strategy should have a great impact on the current medicine. Heart failure is a greatest medical agenda both socially and financially in advanced countries. Clinical application of the present research results is expected not only to cure patients but also to promote the economical efficiency in the society, directly leading to the invention of intellectual properties and new industries. Less

在这项研究中，我们证明，通过使用电子人工脑干任意控制自主神经张力降低了死亡率，并抑制缺血性心力衰竭模型中的心脏重构。在靶向迷走神经的电子治疗中，电子治疗与β-肾上腺素能抑制的组合显示出更显著的改善，表明迷走神经效应不同于β-肾上腺素能抑制。在靶向动脉压力反射传入通路的电子治疗中，迷走神经切断降低了急性心肌缺血后存活率的改善，提示迷走神经传出通路的重要性。接下来，我们推测通过腹部迷走神经的抗炎作用可能有助于改善心力衰竭，并在腹部迷走神经切断的动物中进行了电子治疗。结果表明，腹部迷走神经有助于改善血流动力学，但对改善心功能无明显作用。 ...更多信息改善心肌缺血后的存活率。在这些治疗实验的同时，我们确定了压力感受器转导的动力学特征，并开发了一种新的动脉压力感受器反射中枢功能的鉴定方法。这些研究将为人工脑干与生物系统的整合提供必要的基础。上述使用人工脑干的仿生医学是最先进的医学和尖端工程的融合，在医学史上是独一无二的。由于仿生药物能够通过不同于普通药物交感神经抑制治疗的机制改善心力衰竭的预后，因此目前的治疗策略应该会对当前的医学产生很大的影响。在发达国家，心力衰竭是社会和经济上最大的医疗议程。本研究成果的临床应用不仅有望治愈患者，而且还将促进社会经济效益，直接导致知识产权和新产业的发明。少

项目成果

期刊论文数量（108）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats

DOI：
10.1161/01.cir.0000105721.71640.da
发表时间：
2004-01-06
期刊：
CIRCULATION
影响因子：
37.8
作者：
Li, M;Zheng, C;Sunagawa, K
通讯作者：
Sunagawa, K

Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc.

肌肉机械感受通过重置动脉压力感受神经弧来诱导升压反应。

DOI：
发表时间：
2004
期刊：
Am J Physiol Heart Circ Physiol. 286
影响因子：
0
作者：
Inadama;N.;Murayama;H.;Watanabe;M.;Omura;T.;Yamashita;T.;Kawai;H.;Umehara;T.;Kasahara;T.;Orita;N.;Tsuda;T.;Yamamoto K et al.
通讯作者：
Yamamoto K et al.

Toru Kawada: "A derivative-sigmoidal model reproduces operating-point dependent baroreflex neural arc transfer characteristics"Am J Physiol Heart Circ Physiol. (in press). (2004)

Toru Kawada：“导数 S 形模型再现了工作点相关的压力反射神经弧转移特征”Am J Physiol Heart Circ Physiol。