A PROPHYLACTIC STUDY OF PARTURIENT PARESIS IN COWS -Effects of dietary cation-anion balance-

奶牛产后轻瘫的预防研究-日粮阳离子-阴离子平衡的影响-

• 批准号: 05660363
• 负责人: NAITO Yoshihisa
• 金额: $ 1.34万
• 依托单位: IWATE UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05660363/
• 关键词: parturient paresis; cow; prevention; dietary cation-anion balance; DCAB; metabolic acidosis; calcium metabolism; 1,25 (OH) _2D; カルシウム代謝

In this study, influences of cation exchange resin (Resin) on acid-base status and mineral concentration of blood were examined in rats, sheep and cattle, as a possible model to prevent parturient paresis in cows.(1) The results in rats indicated that diets containg cation exchange resin induce metabolic acidosis and increase the blood concentration of Ca by causing release Ca from bone.(2) In sheep, the levels of blood pH and plasma HCO_3 apparently decreased, while plasma Cl level increased. However, there were no clinical sighs in the sheep developed metabolic acidosis.(3) The results in cattle was also similar to the resuts observed in sheep.In conclusion, these findings suggested that oral administration of Resin was able to adsorb cations in gastro-enteric fluids enand to regulate cation-anion balances in blood in these animals. Therefore, pertinent selection of ion exchange resin was thought to be utilize as a diet additive to prevent parturient paresis.

本研究探讨了阳离子交换树脂（Resin）对大鼠、绵羊和牛血液酸碱状态和矿物质浓度的影响，作为预防奶牛分娩轻瘫的可能模型。(1)结果表明，含阳离子交换树脂的饲料可引起代谢性酸中毒，并通过引起骨钙释放而使血中钙浓度升高。(2)绵羊血液pH值和血浆HCO_3水平明显降低，而血浆Cl水平升高。而发生代谢性酸中毒的绵羊无临床症状。(3)牛的结果也与羊的结果相似。总之，这些结果表明，口服树脂能够吸附胃肠道液中的阳离子，并调节血液中的阳离子-阴离子平衡。因此，选择适当的离子交换树脂作为日粮添加剂，可预防产妇轻瘫。

项目成果

内藤善久: "陽イオン交換樹脂投与が緬羊の酸塩基平衡と無機質とくにCa代謝に及ぼす影響" (発表予定).

Yoshihisa Naito：“施用阳离子交换树脂对绵羊酸碱平衡和矿物质（尤其是钙）代谢的影响”（待提交）。

Won,J.: "Effects of cation exchange Resin,High Chloride-Normal Calcium and High Chloride-High Calcium diet on blood acid-base status and calcium metabolism in rats"

Won,J.：“阳离子交换树脂、高氯-普通钙和高氯-高钙饮食对大鼠血液酸碱状态和钙代谢的影响”

NAITO,Y.: "Effects of administration of cation exchange resin on blood acid-base balance and Ca metabolism in sheep" (Be scheduled to publicate).

NAITO，Y.：“施用阳离子交换树脂对绵羊血液酸碱平衡和钙代谢的影响”（预定出版）。

内藤善久: "乳熱の予防と飼料中の陽陰イオンバランス(速報)" 獣医畜産新報. 46. 244 (1993)

内藤义久：“预防产奶热和饲料中的阳离子和阴离子平衡（初步报告）”《兽医和牲畜报》46. 244（1993）。

NAITO,Y.: "Prevention of parturient paresis and dietary cation-anion balance (Letter)" Journal of Veterinary medicine (in Japanese). 46. 244 (1993)

NAITO,Y.：“产妇轻瘫的预防和膳食阳离子-阴离子平衡（信件）”兽医医学杂志（日语）。