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Engeineering of delta-endotoxin from Bacillus thuringiensis to make a new specificity.

Engeineering of delta-endotoxin from Bacillus thuringiensis to make a new specificity.
苏云金芽孢杆菌δ-内毒素的工程改造使其具有新的特异性。
批准号：
05660385
负责人：
SATO Ryoichi
金额：
$1.34万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
项目状态：
已结题
起止时间：
1993 至 1994
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05660385/
关键词：
Bacillus thuringiensisdelta-endotoxinimmunotoxin組換えタンパク質一本鎖モノクローナル抗体

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英文摘要
To make proteinaceous insecticides which has specificity against harmful insect pests, monoclonal antibodies as specific ligands agaist the proteins on the insect midgut and recombinant delta-endotoxin production system were prepared. After cloning of genes of the monoclonal antibodies we are going to make fused gene of monoclonal antibodies and the toxin and finally produce chimera delta-endotoxin with monoclonal antibody which is toxic to the host who has the antigenic proteins of the antibody.
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