Pathophysiological role of platelet Ca pump in essential hypertensive children in relation to Ca intake

原发性高血压儿童血小板钙泵的病理生理作用与钙摄入量的关系

• 批准号: 05670662
• 负责人: UCHIYAMA Makoto
• 金额: $ 1.15万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670662/
• 关键词: Child; Essential hypertension; Ca pump; Ca intake; Na transport; 本態性高血圧; 高血圧家族歴; 血漿Ca; 尿中Ca

We measured the number of platelet Ca pump receptor, urinary Ca excretion, corrected plasma Ca, and the number of erythrocyte Na pump receptor in 27 hypertensive or normotensive children, and obtained the following results.1) Decreased number of Ca pump receptor was strongly related to the family history of hypertension.2) The numbers of both Ca and Na pump receptors, and corrected plasma Ca were lower in hypertensives than in normotensives, although they were not statistically significant.3) Platelet Ca concentration was negatively correlated with the number of Ca pump receptor.In addition, these factors were measured before and after oral Ca administration (600 mg/day, one to three months) in six children who had very low number of Ca pump receptor, and who wanted to be examined. The following results were obtained.1) The number of Na pump receptor, corrected plasma Ca and urinary Ca excretion were increased, although they were not statistically significant.2) The number of Ca pump receptor, platelet Ca concentration and blood pressure did not change.These findings suggest that intra-and extracellular Ca metabolism may have a significant role in regulating blood pressure in children, and that oral Ca supply may be useful to improve the disturbance of membrane Na pump which is related to the development of essential hypertension in adults.

我们测定了27例高血压或正常血压儿童血小板钙泵受体数目、尿钙排泄、校正血浆钙及红细胞钠泵受体数目，得到以下结果：1)钙泵受体数量减少与高血压家族史密切相关。2)高血压患者Ca、Na泵受体数量及校正血浆Ca均低于正常血压组，但差异无统计学意义。3)血小板钙浓度与钙泵受体数量呈负相关。此外，对6名钙泵受体非常低且希望接受检查的儿童，在口服钙（600 mg/天，1至3个月）前后测量了这些因素。得到了以下结果：1)钠泵受体数量、校正血浆钙、尿钙排泄量均增加，但差异无统计学意义。2)钙泵受体数量、血小板钙浓度及血压无明显变化。这些结果提示，细胞内和细胞外钙代谢可能在儿童血压调节中起重要作用，而口服钙可能有助于改善与成人原发性高血压发生有关的膜钠泵紊乱。

项目成果

内山聖: "本態性高血圧症-小児と成人の接点-" 新潟県医師会報. 520(号). 1-8 (1994)

Kiyoshi Uchiyama：“原发性高血压 - 儿童和成人之间的相互作用”新泻县医学会公告 520（第 1-8 期）（1994 年）。

Makoto Uchiyama: "Genetic factors in essential hypertension, with a special focus on children" Acta Medica et Biologica. 42(4). 137-144 (1994)

Makoto Uchiyama：“原发性高血压的遗传因素，特别关注儿童”Acta Medica et Biologica。

UCHIYAMA MAKOTO: "Risk factors for the development of essential hypertension:long-tern follow-up study in junior high school students in Niigata,Japan" Journal of Human Hypertension. 8. 323-325 (1994)

内山诚：“原发性高血压的危险因素：日本新泻初中生的长期随访研究”《人类高血压杂志》。

UCHIYAMA MAKOTO: "Erythrocyte Na/K flux ratio in relation to sodium intake and a family history of essential hypertension in normotensive children" Journal of Human Hypertension. 7. 47-51 (1993)

内山诚：“正常血压儿童中红细胞 Na/K 通量比与钠摄入量和原发性高血压家族史的关系”《人类高血压杂志》。

Makoto Uchiyama: "Risk factors for the development of essential hypertension : long-term follow-up study in junior high school students in Niigata, Japan" J.Human Hypertension. 8. 323-325 (1994)

Makoto Uchiyama：“原发性高血压的危险因素：对日本新泻初中生的长期随访研究”J.Human Hypertension。