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CHRONOBIOGICAL BASES OF PREMENSTRUAL SLEEP AND MOOD DISORDERS

经前睡眠和情绪障碍的时间生物学基础

基本信息

批准号：
13470200
负责人：
UCHIYAMA Makoto
金额：
$ 8.26万
依托单位：
National Center of Neurology and Psychiatry
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470200/
关键词：
SLEEP SLEEPINESS PREMENSTRUAL SYNDROME OVARIAN STEROIDS MELATONIN SUPRACHIASMATIC NUCLEUS CLOCK GENE CIRCADIAN PACEMAKER

项目摘要

We previously reported a patient suffering from premenstrual syndrome in which sleep/wake and core body temperature rhythms displayed phase advances in the follicular phase and phase delays in the luteal phase. To see effects of ovarian steroid hormones on the circadian pacemaker, we conducted animal experiments and found that estrogen phase-advanced the circadian expression of Per2 gene in the suprachiasmatic nucleus but had no effects on that of Pen gene, suggesting that Per1 and Per2 genes in the suprachiasmatic nucleus were differentially regulated by estrogen. These results provide an explanation for phase advances in the follicular phase in premenstrual syndrome. Further analyses on molecular mechanisms of estrogen revealed that the phase advance of Per2 gene expression caused by estrogen was mainly regulated by interactions between SRC-1 and CLOCK in the suprachiasmatic nucleus. We applied an ultrashort sleep-wake schedule to eight healthy women and studied diurnal fluctuations in sleep propensity, sleepiness, rectal temperature, and serum concentrations of melatonin, thyroid-stimulating hormone, and cortisol in the follicular and luteal phases. In the luteal phase, amplitude of core body temperature, total melatonin secretions, and amplitudes of TSH and cortisol rhythms were significantly decreased, whereas sleepiness and occurrence of slow-wave sleep during the daytime were significantly increased. Differences in the amount of daytime slow-wave sleep across the menstrual cycle were positively correlated with differences in the daily mean rectal temperature. The findings suggest that the amplitude of circadian oscillation may be dampened in the luteal phase. Increased daytime sleepiness in the luteal phase may be associated with increased daytime slow-wave sleep, due possibly to changes in thermoregulation in the luteal phase.

我们之前报道了一位患有经前综合征的患者，其中睡眠/觉醒和核心体温节律在卵泡期表现出相位提前，而在黄体期表现出相位延迟。为了观察卵巢类固醇激素对昼夜节律起搏器的影响，我们进行了动物实验，发现雌激素阶段推进视交叉上核Per2基因的昼夜节律表达，而对Pen基因的昼夜节律表达没有影响，提示视交叉上核Per1和Per2基因受到雌激素的差异调节。这些结果为经前综合征卵泡期提前提供了解释。进一步对雌激素的分子机制进行分析，发现雌激素引起Per2基因表达的期进主要受视交叉上核SRC-1与CLOCK的相互作用调控。我们对8名健康女性采用了超短睡眠-觉醒时间表，研究了她们在卵泡期和黄体期的睡眠倾向、嗜睡、直肠温度和血清褪黑激素、促甲状腺激素和皮质醇浓度的日波动。在黄体期，核心体温幅度、褪黑素分泌总量、TSH和皮质醇节律幅度明显降低，而白天嗜睡和慢波睡眠的发生明显增加。在整个月经周期中，白天慢波睡眠时间的差异与每日平均直肠温度的差异呈正相关。研究结果表明，昼夜节律振荡的幅度可能在黄体期被抑制。黄体期白天嗜睡增加可能与白天慢波睡眠增加有关，这可能是由于黄体期体温调节的变化。

项目成果

期刊论文数量（212）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Shibui K, Uchiyama M,, Kim K, Tagaya H, Kuriyama K, Suzuki H, Kamei Y, Hayakawa T, Okawa M, Takahashi K: "Melatonin, cortisol and thyroid-stimulating hormone rhythms are delayed in patients with delayed sleep phase syndrome"Sleep and Biological Rhythms. 1

Shibui K、Uchiyama M、Kim K、Tagaya H、Kuriyama K、Suzuki H、Kamei Y、Hayakawa T、Okawa M、Takahashi K：“睡眠相位延迟综合征患者的褪黑激素、皮质醇和促甲状腺激素节律延迟

DOI：
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0
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田ヶ谷浩邦, 内山真: "不眠症とその対策"成人病と生活習慣病. 33. 1184-1188 (2003)

Hirokuni Tagaya，Makoto Uchiyama：“失眠及其对策”成人和生活方式疾病。33。1184-1188（2003）。

DOI：
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影响因子：
0
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通讯作者：

亀井雄一, 田ヶ谷浩邦, 金圭子, 栗山健一, 尾崎章子, 渋井佳代, 有竹清夏, 内山真: "エビデンスの使い方:睡眠障害"臨床精神薬理. 6. 1035-1047 (2003)

Yuichi Kamei、Hirokuni Tagaya、Keiko Kane、Kenichi Kuriyama、Akiko Ozaki、Kayo Shibui、Kiyoka Aritake、Makoto Uchiyama：“如何使用证据：睡眠障碍”临床精神药理学。6. 1035-1047 (2003)。