Measurements of erythrocyte Na pump receptor and lymphocyte adrenergic receptor in relation to digitalis-therapy in cardiac failure

对9例4个月~9岁的充血性心力衰竭患儿用洋地黄治疗前后的红细胞Na泵受体和淋巴细胞肾上腺素能(β)受体进行了测定。获得了以下结果(均值*SD)。1)心力衰竭患儿β受体数量显著低于年龄匹配的对照组(8.7±3.5vs16.1×5.3，P<0.01)。2)洋地黄治疗后，β-受体数量较治疗前显著增加(12.7±4.6，P&lt；0.01)。然而，这仍然低于对照组儿童，尽管这在统计学上没有显著意义。3)心力衰竭组钠泵受体数目低于对照组，但差异无统计学意义(6.9±2.8vs7.4×2.1，P&gt；0.05)。4)洋地黄治疗后Na泵受体数目较治疗前显著减少(4.1±1.3，P&lt；0.01)。这些结果表明，测量β受体的数量可能有助于评估充血性心力衰竭的病情，但对于相同的目的，测量钠泵受体的数量可能没有预期的那么有用。

We measured the numbers of erythrocyte Na pump receptor and lymphocyte adrenergic (beta -) receptor before and after treatment with digitalis in 9 children with congestive heart failure aged 4 months to 9 years. The following results (mean* SD) were obtained. 1)The number of beta -receptor was significantly decreased in children with heart failure than in age-matched control children (8.7*3.5 vs 16.1*5.3, P<0.01). 2)After treatment with digitalis, the number of beta -receptor was significantly increased (12.7*4.6, P<0.01) compared with that before treatment. However, it was still lower than that in control children, although this was not statistically significant. 3)The number of Na pump receptor was lower in children with cardiac failure than in control children, although this was not statistically significant (6.9*2.8 vs 7.4*2.1, P>0.05). 4)After treatment with digitalis, the number of Na pump receptor was significantly decreased (4.1*1.3,P<0.01) compared with that before treatment. However, it did not correlate with plasma concentration of digoxin.These findings suggest that measurement of the number of beta -receptor may be useful in evaluating the condition of congestive cardiac failure, however measurement of the number of Na pump receptor may be less useful than expected for the same purpose.