Measurements of erythrocyte Na pump receptor and lymphocyte adrenergic receptor in relation to digitalis-therapy in cardiac failure

红细胞钠泵受体和淋巴细胞肾上腺素受体的测定与心力衰竭洋地黄治疗的关系

• 批准号: 03670501
• 负责人: UCHIYAMA Makoto
• 金额: $ 0.9万
• 依托单位: Niigata University School of Medicine (1992)大分医科大学 (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670501/
• 关键词: Cardiac failure; digitalis; Na pump receptor; adrenergic receptor; children; 赤血球膜Naポンプ受容体; リンパ球交感神経受容体

We measured the numbers of erythrocyte Na pump receptor and lymphocyte adrenergic (beta -) receptor before and after treatment with digitalis in 9 children with congestive heart failure aged 4 months to 9 years. The following results (mean* SD) were obtained. 1)The number of beta -receptor was significantly decreased in children with heart failure than in age-matched control children (8.7*3.5 vs 16.1*5.3, P<0.01). 2)After treatment with digitalis, the number of beta -receptor was significantly increased (12.7*4.6, P<0.01) compared with that before treatment. However, it was still lower than that in control children, although this was not statistically significant. 3)The number of Na pump receptor was lower in children with cardiac failure than in control children, although this was not statistically significant (6.9*2.8 vs 7.4*2.1, P>0.05). 4)After treatment with digitalis, the number of Na pump receptor was significantly decreased (4.1*1.3,P<0.01) compared with that before treatment. However, it did not correlate with plasma concentration of digoxin.These findings suggest that measurement of the number of beta -receptor may be useful in evaluating the condition of congestive cardiac failure, however measurement of the number of Na pump receptor may be less useful than expected for the same purpose.

本文测定了9例4个月~ 9岁充血性心力衰竭患儿洋地黄治疗前后红细胞钠泵受体和淋巴细胞肾上腺素能（β-）受体的数量。获得以下结果（平均值 * SD）。1)心力衰竭组β受体数量明显低于同龄对照组（8.7* 3.5vs16.1 *5.3，P<0.01）。2)洋地黄治疗后，β受体数量较治疗前明显增加（12.7*4.6，P<0.01）。然而，它仍然低于对照组儿童，尽管这在统计学上并不显著。3)心力衰竭患儿的钠泵受体数量低于对照组，但无统计学意义（6.9*2.8 vs 7.4*2.1，P>0.05）。4)治疗后与治疗前比较，Na泵受体数目明显减少（4.1 × 1.3，P <0.01）。这些结果表明，β受体数量的测定可能有助于评价充血性心力衰竭的病情，而钠泵受体数量的测定可能不如预期的有用。

项目成果

Makoto Uchiyama Hiroshi Hayakawa Teruyuki Ogawa: "Alpha-and beta-adrenergic receptors in children with essential hypertension(測定方法の確立)" Acta Paediatrica Japonica. 34. 511-515 (1992)

Makoto Uchiyama Hiroshi Hayakawa Teruyuki Okawa：“原发性高血压儿童的α-和β-肾上腺素受体（测量方法的建立）”Acta Paediatrica Japonica. 34. 511-515 (1992)。

Makoto UCHIYAMA,Hiroshi HAYAKAWA,Teruyuki OGAWA(内山 聖,早川 広史,小川 照之): "Alpha-and beta-adrenergic receptors in children with essential hypertension" Acta Paediatrica Japonica. 34. 511-515 (1992)

Makoto UCHIYAMA、Hiroshi HAYAKAWA、Teruyuki OGAWA（Satoshi Uchiyama、Hiroshi Hayakawa、Teruyuki Okawa）：“原发性高血压儿童中的α-和β-肾上腺素受体”Acta Paediatrica Japonica 34. 511-515 (1992)。

Makoto Uchiyama, Hiroshi Hayakawa, Teruyuki Ogawa: "Alpha- and beta-adrenergic receptors in children with essential hypertension (Establishment of the method of measuring adrenergic receptors in children)" Acta Paediatrica Japonica. 34(5). 511-515 (1992)

Makoto Uchiyama、Hiroshi Hayakawa、Teruyuki Okawa：“原发性高血压儿童的α-和β-肾上腺素受体（儿童肾上腺素受体测量方法的建立）”Acta Paediatrica Japonica。