Measurements of erythrocyte Na pump receptor and lymphocyte adrenergic receptor in relation to digitalis-therapy in cardiac failure

本文测定了9例4个月~ 9岁充血性心力衰竭患儿洋地黄治疗前后红细胞钠泵受体和淋巴细胞肾上腺素能（β-）受体的数量。获得以下结果（平均值 * SD）。1)心力衰竭组β受体数量明显低于同龄对照组（8.7* 3.5vs16.1 *5.3，P<0.01）。2)洋地黄治疗后β受体数量较治疗前显著增加（12.7 × 4.6，P<0.01）。然而，它仍然低于对照组儿童，尽管这在统计学上并不显著。3)心力衰竭患儿的钠泵受体数量低于对照组，但无统计学意义（6.9*2.8 vs 7.4*2.1，P>0.05）。4)治疗后与治疗前比较，Na泵受体数目明显减少（4.1 × 1.3，P <0.01）。这些结果表明，β受体数量的测定可能有助于评价充血性心力衰竭的病情，而钠泵受体数量的测定可能不如预期的有用。

We measured the numbers of erythrocyte Na pump receptor and lymphocyte adrenergic (beta -) receptor before and after treatment with digitalis in 9 children with congestive heart failure aged 4 months to 9 years. The following results (mean* SD) were obtained. 1)The number of beta -receptor was significantly decreased in children with heart failure than in age-matched control children (8.7*3.5 vs 16.1*5.3, P<0.01). 2)After treatment with digitalis, the number of beta -receptor was significantly increased (12.7*4.6, P<0.01) compared with that before treatment. However, it was still lower than that in control children, although this was not statistically significant. 3)The number of Na pump receptor was lower in children with cardiac failure than in control children, although this was not statistically significant (6.9*2.8 vs 7.4*2.1, P>0.05). 4)After treatment with digitalis, the number of Na pump receptor was significantly decreased (4.1*1.3,P<0.01) compared with that before treatment. However, it did not correlate with plasma concentration of digoxin.These findings suggest that measurement of the number of beta -receptor may be useful in evaluating the condition of congestive cardiac failure, however measurement of the number of Na pump receptor may be less useful than expected for the same purpose.