ACTION OF NITRIC OXIDE ON THE INTERNAL URETHRAL SPHINCTER FUNCTION
一氧化氮对尿道内括约肌功能的作用
基本信息
- 批准号:05671297
- 负责人:
- 金额:$ 1.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1994
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The present study was performed to investigate action of nitric oxide on the internal urethral sphincter function. Female rats were anesthetzed with urethane. The bladder neck was ligated in order to measure independently intravesical pressure and internal urethral pressure. Under condition of abolishment of the urethral striated muscle activity by the intravenous administration of pancronium bromide, the bladder and urethral pressure were continuosly recorded during rhythmic isovolumetric bladder contractions before and after intraarterial administration of the following drugs. Used drugs were L-arginine from which nitric oxide is synthetized, L-NMMA,L-NAME which inhibit the synthesis of nitric oxide from L-arginine, and methylene blue which inhibits the activation of soluble guanylyl cyclase. Before the administration of each drug, rhythmic bladder contractions with concomitant urethral relaxations were occurred. Administration of L-arginine produced a decrese in urethral pressure. A … More dministration of L-NMMA,L-NAME and methylene blue produced an inhibition of the internal urethral sphincter relaxation during rhythmic bladder contractions. The nitric oxide/cyclic GMP pathway seems to take an important role for the internal urethral sphincter relaxation.Decerebrate dogs were used to examine the effect of L-arginine and methylene blue on the isovolumetric bladder contractions in response to bladder fillig and electrical stimulation of pontine micturition center. In the isovolumetric bladder contractions in response to bladder filling, L-arginine produced an increase in bladder capacity and a decrease in bladder contraction pressure. Methylene blue produced an inhibition of effect of L-arginine. In the isovolumetric bladder contractions in response to electrical stimulation of pontine micturition center, methylene blue produced an increase in the bladder contraction pressure and duration of bladder contraction. The nitric oxide/cyclic GMP pathway seems to take certain role for bladder activity. Less
本研究旨在探讨一氧化氮对尿道内括约肌功能的影响。用乌拉坦麻醉雌性大鼠。结扎膀胱颈以独立测量膀胱内压和尿道内压。在静脉注射潘可溴铵(Pancronium bromide)消除尿道横纹肌活动的条件下,连续记录动脉注射下列药物前后膀胱节律性等容收缩时的膀胱和尿道压力。使用的药物是合成一氧化氮的L-精氨酸、抑制L-精氨酸合成一氧化氮的L-NMMA、L-NAME和抑制可溶性鸟苷酸环化酶活化的亚甲蓝。每种药物给药前,发生节律性膀胱收缩伴尿道松弛。应用L-精氨酸可使尿道压力下降。一 ...更多信息 L-NMMA、L-NAME和亚甲蓝对膀胱节律性收缩时的内尿道括约肌松弛有抑制作用。用去脑犬观察了L-精氨酸和亚甲蓝对膀胱充盈和电刺激桥脑排尿中枢引起的等容膀胱收缩的影响。在等容膀胱收缩膀胱充盈,L-精氨酸产生膀胱容量的增加和膀胱收缩压力的降低。亚甲蓝对L-精氨酸的作用有抑制作用。在电刺激脑桥排尿中枢引起的等容膀胱收缩中,亚甲蓝使膀胱收缩压和收缩持续时间增加。一氧化氮/环鸟苷酸途径似乎对膀胱活动起一定作用。少
项目成果
期刊论文数量(30)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kawahara,T.,Nishizawa,O.et al.: "Effect of the Inhibitors of nitric oxide/cyclic GMP pathway of the internal urethral relaxation in anesthetized rats" Proceedings of the 23rd Annual Meeting of the International Continence Society. AbstractN 102 (1993)
Kawahara,T.,Nishizawa,O.等人:“一氧化氮/环 GMP 通路抑制剂对麻醉大鼠尿道内松弛的影响”国际节制协会第 23 届年会论文集。
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- 影响因子:0
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Kawahara,T.: "Effect of the inhibitors of the nitric oxede/cyclic GMP pathway on the internal urethral relaxation anesthetized rats." Proceedings of 23rd Annual Meeting of the International Continence Society. (abstract). 102 (1993)
Kawahara,T.:“一氧化氮/环鸟苷酸途径抑制剂对麻醉大鼠尿道内松弛的影响。”
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Noto,H.: "Effect of L-arginine and methylene blue on the micturition reflex in deceredrated dogs." Proceedings of 23rd Annual Meeting of the International continence society. (abstract). 99 (1993)
Noto,H.:“L-精氨酸和亚甲蓝对退化狗排尿反射的影响。”
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Fujieda, N.: "Effect of L-arginine on the micturition reflex in decerebrate dogs" J.Smooth Muscle Res. 29. 292-293 (1993)
Fujieda, N.:“L-精氨酸对去大脑狗排尿反射的影响”J.Smooth Muscle Res。
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Fujieda,N: "The effects of guanylate cyclase inhibitor on the urinary blauder function in decerebrate dogs." J.Urol.115(abstract). 480A-1010 (1994)
Fujieda,N:“鸟苷酸环化酶抑制剂对去大脑狗尿囊功能的影响。”
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NISHIZAWA Osamu其他文献
NISHIZAWA Osamu的其他文献
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- 批准号:
23592364 - 财政年份:2011
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$ 1.15万 - 项目类别:
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20591876 - 财政年份:2008
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$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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神经生长因子在梗阻性膀胱功能障碍中的作用和 mRNA 神经生长因子的定位
- 批准号:
07671705 - 财政年份:1995
- 资助金额:
$ 1.15万 - 项目类别:
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Role of Bladder Nerve Growth Factor on the lower Urinary Tract Dysfunction
膀胱神经生长因子对下尿路功能障碍的作用
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02670697 - 财政年份:1990
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)