Basic and clinical aspects of LUTS induced by cold stress

冷应激引起的 LUTS 的基础和临床方面

• 批准号: 23592364
• 负责人: NISHIZAWA Osamu
• 金额: $ 3.33万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592364/
• 关键词: 冷えストレス; 国際前立腺症状スコア; 過活動膀胱症状スコア; アドレナリン受容体; 膀胱粘膜; セロトニン受容体; 大建中湯; 過活動膀胱症状質問票; セロトニン

Lower urinary tract symptoms(LUTS) induced by cold stress has not been sufficiently studied. Autonomic nervous system receptors mRNA were analyzed in bladder mucosa of patients with LUTS/benign prostatic obstruction. There was an increased expression of alpha 1d-AR, beta 3 AR, serotonin 2b, 3a, 7 mRNA in the bladder mucosa. Serotonin mechanism may take a role in LUTS induced by cold stress. 50 people who visited a public health management seminar were studied. The participants were devided into two groups-cold sensitive and non-sensitive- according to self-described sensitivity to cold stress. Daily exercise and lifestyle modification was effective for LUTS in cold sensitive people. Daikenchuto, a pharmaceutical-grade traditional Japanese medicine, were administered to the refratory LUTS patients with constipation or cold sensitivity. Daikenchuto improved LUTS suggesting as a consequence of improvement of constipation or cold sensitivity.

冷应激引起的下尿路症状（LUTS）尚未得到充分研究。对 LUTS/良性前列腺梗阻患者的膀胱粘膜中的自主神经系统受体 mRNA 进行了分析。膀胱粘膜中α1d-AR、β3AR、血清素2b、3a、7 mRNA的表达增加。 5-羟色胺机制可能在冷应激诱发的 LUTS 中发挥作用。对参加公共卫生管理研讨会的 50 人进行了研究。根据参与者自我描述的对冷应激的敏感性，将参与者分为两组：冷敏感组和非敏感组。日常锻炼和改变生活方式对寒冷敏感人群的 LUTS 有效。 Daikenchuto 是一种医药级的日本传统药物，用于治疗便秘或对寒冷敏感的难治性 LUTS 患者。 Daikenchuto 改善了 LUTS，表明这是便秘或寒冷敏感性改善的结果。

项目成果

The relationship between toe temperature and lower urinary tract symptoms.

脚趾温度与下尿路症状之间的关系。

• 发表时间: 2012
• 期刊: LUTS
• 影响因子: 1.3
• 作者: Inoue;H.;Ishizuka;O.;Imamura;T.;Yamagishi;T.;Noguchi;W.;Yokoyama;H.;Kurizaki;Y.;Nishizawa;O
• 通讯作者: O

冷え・便秘を合併する排尿障害に対する大建中湯の治療効果

大健中汤对泌尿系病症寒便秘的治疗作用

• 发表时间: 2013
• 作者: Inoue H;Ishizuka O;Nishizawa O et al;皆川倫範,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修,西澤理
• 通讯作者: 皆川倫範,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修,西澤理

The relationship between toe temperature and lower urinary tract symptoms

脚趾温度与下尿路症状的关系

• 发表时间: 2012
• 期刊: LUTS
• 影响因子: 1.3
• 作者: Inoue;H.;Ishizuka;O.;Imamura;T.;Yamagishi;T.;Noguchi;W.;Yokoyama;H.;Kurizaki;Y.;Nishizawa;O.
• 通讯作者: O.

下部尿路閉塞モデルラットにおける冷えストレス誘発排尿筋過活動に対するナフトピジルの薬理効果の検討

萘哌地尔对冷应激所致下尿路梗阻模型大鼠逼尿肌过度活动的药理作用研究

• 发表时间: 2013
• 作者: Yamagishi;T.;Ishizuka;O.;Imamura;T.;Noguchi;W.;Yokoyama;H.;Kurizaki;Y.;Nishizawa;O.;皆川倫範,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修,西澤理;山岸貴裕,石塚修,今村哲也,野口渉,横山仁,小川輝之,栗崎功己,西澤理
• 通讯作者: 山岸貴裕,石塚修,今村哲也,野口渉,横山仁,小川輝之,栗崎功己,西澤理

Alpha1-adrenergic receptors mediate detrusor overactivity induced by cold stress in rats with bladder outlet obstruction

α1-肾上腺素能受体介导膀胱出口梗阻大鼠冷应激诱导的逼尿肌过度活动

• DOI: 10.1002/nau.22543
• 发表时间: 2014
• 期刊: Neurourology and urodyamics
• 作者: Yamagishi T;Ishizuka O;Imamura T;Yokoyama H;Ogawa T;Kurizaki Y;Nishizawa O;Andersson KE
• 通讯作者: Andersson KE