Role of Bladder Nerve Growth Factor on the lower Urinary Tract Dysfunction

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In female Wbister rats, bladder weights at 1 week, and 2, 3, 4 weeks after spinal cord injury on 10 weeks after birth showed respectively 153.7<plus-minus>51.7, 241.2<plus-minus>112.7, 176.6<plus-minus>136.6, and 544.0<plus-minus>213.3 mg. Body weights showed respectively 133.3<plus-minus>7.5, 140.0<plus-minus>8.2, 158.9<plus-minus>16.6, and 125.0<plus-minus>16.6 g. In the control rats, bladder weights at 10, 11, 12, 13, 14 weeks after birth showed respectively 60.6<plus-minus>5.6, 43.9<plus-minus>6.2, 42.2<plus-minus>6.0, 41.5<plus-minus>6.5, and 40.5<plus-minus>5.9 mg. Body weights showed respectively 160.0<plus-minus>4.5, 162.0<plus-minus>7.5, 166.0<plus-minus>8.0, 161.0<plus-miThe amount of NGF measured in control bladders at 11, 12, 13, 14 weeks after birth showed respectively 326.9, 478.5, 85.5, and 65.7 ng/ g wet weight. While, the amount of NGF measured in the bladders at 1 week, and 2, 3, 4 weeks after spinal cord injury showed respectively 292.5, 392.4, 280.3, and 708.2 ng/ g wet weight. We could not find a significant difference between the amounts of bladder NGF in the both control and spinal cord injury groups.The procedure of the spinal cord injury at the junction of the thoracic and lumbar vertebrae might decrease the activity of the sacral micturition center. Further study is necessary to determine exact role of the bladder NGF on the various lower urinary tract neurogenic dysfunction.