Role of Bladder Nerve Growth Factor on the lower Urinary Tract Dysfunction

膀胱神经生长因子对下尿路功能障碍的作用

• 批准号: 02670697
• 负责人: NISHIZAWA Osamu
• 金额: $ 1.34万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670697/
• 关键词: Bladder Nerve Growth Factor; Spinal Cord Injury; Lower Urinary Tract Function; 不安定膀胱

In female Wbister rats, bladder weights at 1 week, and 2, 3, 4 weeks after spinal cord injury on 10 weeks after birth showed respectively 153.7<plus-minus>51.7, 241.2<plus-minus>112.7, 176.6<plus-minus>136.6, and 544.0<plus-minus>213.3 mg. Body weights showed respectively 133.3<plus-minus>7.5, 140.0<plus-minus>8.2, 158.9<plus-minus>16.6, and 125.0<plus-minus>16.6 g. In the control rats, bladder weights at 10, 11, 12, 13, 14 weeks after birth showed respectively 60.6<plus-minus>5.6, 43.9<plus-minus>6.2, 42.2<plus-minus>6.0, 41.5<plus-minus>6.5, and 40.5<plus-minus>5.9 mg. Body weights showed respectively 160.0<plus-minus>4.5, 162.0<plus-minus>7.5, 166.0<plus-minus>8.0, 161.0<plus-miThe amount of NGF measured in control bladders at 11, 12, 13, 14 weeks after birth showed respectively 326.9, 478.5, 85.5, and 65.7 ng/ g wet weight. While, the amount of NGF measured in the bladders at 1 week, and 2, 3, 4 weeks after spinal cord injury showed respectively 292.5, 392.4, 280.3, and 708.2 ng/ g wet weight. We could not find a significant difference between the amounts of bladder NGF in the both control and spinal cord injury groups.The procedure of the spinal cord injury at the junction of the thoracic and lumbar vertebrae might decrease the activity of the sacral micturition center. Further study is necessary to determine exact role of the bladder NGF on the various lower urinary tract neurogenic dysfunction.

雌性Wbistar大鼠脊髓损伤后1周、2周、3周、4周的膀胱重分别为153.7、241.2、112.7、176.6、544.0、213.3 mg。对照组大鼠出生后10、11、12、13、14周的膀胱重分别为133.3、11、12、13、14周的膀胱重量分别为60.6、5.6、43.9、125.0、42.2、16.6g。正负&gt；6.0、41.5&lt；正负&gt；6.5和40.5&lt；正负&gt；5.9 mg。出生后11、12、13、14周龄对照组膀胱中神经生长因子含量分别为326.9、478.5、85.5和65.7 ng/g湿重。脊髓损伤后1周、2周、3周、4周膀胱组织中神经生长因子含量分别为292.5、392.4、280.3、708.2 ng/g湿重。对照组和脊髓损伤组大鼠膀胱NGF含量无明显差异，胸腰椎交界处脊髓损伤可能降低了大鼠骶骨排尿中枢的活动。膀胱NGF在各种下尿路神经源性功能障碍中的确切作用有待进一步研究。

项目成果

西沢 理: "ラット脊損膀胱の神経成長因子について" 日本パラプレジア医学会雑誌.

Osamu Nishizawa：“关于大鼠脊髓损伤膀胱中的神经生长因子”，日本截瘫医学会杂志。

西沢 理: "ラット脊髄損傷膀胱の神経成長因子の変動" 日泌尿会誌.

Osamu Nishizawa：“脊髓损伤大鼠膀胱中神经生长因子的变化”日本泌尿学会杂志。