Changes in the function of neutrophils from diabetic rats

糖尿病大鼠中性粒细胞功能的变化

• 批准号: 05671838
• 负责人: NAKAGAWA Yasuhito
• 金额: $ 1.28万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671838/
• 关键词: Arachidonic acid; Leukotriene; Neutrophil; Aggregation; Diabetes; リン脂質

The aim of this project was to examine a possible link between changes in the metabolism of arachidonic acid and impairment of the function of rats neutrophils in the state of diabetes induced by streptozotocin. We found several results as follows ;1) Profound decreases in the proportion of arachidonic acid of phospholipids were found in neutrophils from diabetic rats.2) There were decreases in the production of free arachidonic acid LTB4 in A23187-stimulated from diabetic rats as compared to those from normal rats.3) Aggregation of neutrophils provoked by A23187 was significantly suppressed in neutrophils from diabetic rats. However, arachidonic acid induced aggregations of neutrophils from diabetic and normal rats to similar extents.The present study suggest that diabetes-associated changes in arachidonic acid metabolism might play a critical role in the modulation of aggregation of neutrophils.

本项目旨在探讨链脲佐菌素诱导的糖尿病大鼠花生四烯酸代谢变化与中性粒细胞功能损害之间的可能联系。我们发现了以下几个结果：1)糖尿病大鼠中性粒细胞中磷脂中花生四烯酸的比例明显降低。2)与正常大鼠相比，糖尿病大鼠受a23187刺激后游离花生四烯酸LTB4的产生减少。3) A23187诱导的中性粒细胞聚集明显抑制糖尿病大鼠中性粒细胞聚集。然而，花生四烯酸诱导糖尿病大鼠和正常大鼠中性粒细胞聚集的程度相似。目前的研究表明，糖尿病相关的花生四烯酸代谢的变化可能在中性粒细胞聚集的调节中起关键作用。

项目成果

Qizhi Hu: "Changes of arachidonic acid in tissues during the progession of diabetes" J.Biochem.115. 405-408 (1994)

Qizhi Hu：“糖尿病进展过程中组织中花生四烯酸的变化”J.Biochem.115。

Qizhi Hu: "Changes of arachidonic acid in tissues during the progression of diabetes" J.Biochem. 115. 405-408 (1994)

胡启志：“糖尿病进展过程中组织中花生四烯酸的变化”J.Biochem。