Novel function of cardiolipin in the gonad development ofC. Elegans

心磷脂（CL）是一种特异性定位于线粒体内膜的酸性磷脂。通过与各种线粒体蛋白相互作用，CL有助于维持这些线粒体蛋白的结构和功能。本研究通过对C. elegans，我们证明了CL耗竭选择性地导致生殖细胞而不是体细胞中线粒体功能和形态异常。这是第一项研究，以显示不同的细胞类型之间的不同的亲和力，以CL消耗体内。

Cardiolipin (CL) is an acidic phospholipid specifically localized in mitochondrial inner membrane. By interacting with various mitochondrial proteins, CL contributes to the maintenance of the structure and function of those mitochondrial proteins. In this study, by analyzing deletion mutants of a CL synthase gene (crls-1) in C. elegans, we demonstrated that CL depletion selectively caused abnormal mitochondrial function and morphology in germ cells but not in somatic cells. This is the first study to show varying susceptibilities among different cell types to CL depletion in vivo.