SUBCLINICAL NEUROPSYCHOLOGICAL AND BEHAVIORAL EFFECTS AMONG WORKERS EXPOSED TO LONG TERM LOW LEVEL OF ORGANIC SOLVENTS

长期接触低水平有机溶剂的工人的亚临床神经心理和行为影响

• 批准号: 06454240
• 负责人: MIYAKE Hirotsugu
• 金额: $ 3.39万
• 依托单位: SAPPORO MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454240/
• 关键词: neurobehavioral tests; neuropsychological effects; organic solvents; chronic exposure; neuroconduction velocity; color vision; toluene; stirene; シクロヘキサン; 神経行動テストバッテリ-; 振動覚; 暴露影響評価; 神経行動毒性; 運動(感覚)神経伝導速度; 混合溶剤; 尿中代謝物

The neurotoxicity of organic solvents is one of the most important emerging issues in the field of occupational health. We conducted several epidemiological survey on the neurobehavional and psychological effects using different kind of tests for central nervous system, neuroconduction velocity of peripheral nerves, color vision and other neurophysiological tests among Japanese workers who have been exposed to stirene, toluene, cyclohexane etc. There were dose-dependent relationship between exposure levels of stirene and toluene and decrements of some neurobehavioral tests performance. After adjusting confounding factors, such as age, sex, educational attainments, alcohol intake, etc, urinary mandelic acid or hippuric acid had a significant positive relationship with color discrimination index, ulnar and peroneal MDL,and other performance score. Our study suggests that a low level of stirene, or toluene exposure involves the risk of inducing adverse effects on the central and peripheral nerve system. The studies also indicated that these tests are very sensitive parameters for detecting subclinical toxic neuropathy.

有机溶剂的神经毒性是职业健康领域最重要的新问题之一。我们对接触过苯乙烯、甲苯、环己烷等的日本工人进行了多项流行病学调查，通过不同的中枢神经系统测试、周围神经传导速度、色觉等神经生理学测试来了解其神经行为和心理影响。苯乙烯和甲苯的暴露水平与某些物质的减少之间存在剂量依赖关系。 神经行为测试表现。调整年龄、性别、受教育程度、饮酒等混杂因素后，尿扁桃酸或马尿酸与颜色辨别指数、尺骨和腓骨MDL以及其他表现评分呈显着正相关。我们的研究表明，低水平的苯乙烯或甲苯暴露可能会对中枢和周围神经系统产生不利影响。研究还表明，这些测试是检测亚临床中毒性神经病的非常敏感的参数。

项目成果

Kishi R,Chen BQ,Katakura Y,Ikeda T,Miyake H.: "Effects of prenatal exposure to styrene on the neurobehavioral development,activity,motor coordination and learning behavior of rats" Neurotoxicology and Teratology. 17. 121-130 (1995)

Kishi R，Chen BQ，Katakura Y，Ikeda T，Miyake H.：“产前接触苯乙烯对大鼠神经行为发育、活动、运动协调和学习行为的影响”神经毒理学和畸胎学。

Kishi R,Bing Qing Chen, Katakura Y,Ikeda T,Miyake H: "Effect of Prenatal Exposure to Stirene on the Neurobehavioral Development, Activity, Motor Coordination, and Learning Behavior of Rats." Neurotoxicology and Teratology. 17 No2. 121-130 (1995)

Kishi R、Bing Qing Chen、Katakura Y、Ikeda T、Miyake H：“产前接触苯乙烯对大鼠神经行为发育、活动、运动协调和学习行为的影响”。

Yuasa J,Kishi R,Eguchi T,Harabuchi I,Kawai T,Ikeda M,Sugimoto R,Matsumoto H,Miyake H.: "Investigation on neurotoxicity of occupational exposure to cyclohexane : a neurophysiological study." Occupational and Environmental Medicine. 53. 174-179 (1996)

Yuasa J，Kishi R，Eguchi T，Harabuchi I，Kawai T，Ikeda M，Sugimoto R，Matsumoto H，Miyake H.：“职业接触环己烷的神经毒性调查：一项神经生理学研究。”

Eguchi T,Kishi R,Harabuchi I,Yuasa J,Arata Y,Katakura Y,Miyake H.: "Impaired color Cdiscrimination among workers exposed to styrene:relevance of a urimary metabolite" Occupational and Environmental Mediciue. 52. 534-538 (1995)

Eguchi T，Kishi R，Harabuchi I，Yuasa J，Arata Y，Katakura Y，Miyake H.：“接触苯乙烯的工人中颜色歧视受损：尿代谢物的相关性”职业和环境医学。

Kishi R,Chen BQ,: "Effects of prenatal exposure to styrene on the neurobehavioral development,activity, motor coordination and learning behavior of rats" Neurotoxicology and Teratology. 17. 141-130 (1995)

Kishi R，Chen BQ，：“产前接触苯乙烯对大鼠神经行为发育、活动、运动协调和学习行为的影响”神经毒理学和畸胎学。