Development of Psychobehavicral Performance Tests in the Assessment of Soivents Toxicity

药物毒性评估中心理行为表现测试的发展

• 批准号: 63570260
• 负责人: MIYAKE Hirotsugu
• 金额: $ 1.28万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570260/
• 关键词: Organic solvents; Central nervous system; Test battery; WHO core test; Painter; Cognitive function; HAND eye coordination; WAIS; central nervous system dysfunction; organic solvents; psychobehavioral test; batteries; screening; human experime

Subjects and Methods. Eighty-one male painters completed a symptom questionnaire. Twenty subjects underwent both questionnaire and neuropsychological examinations which consisted of a block design test (WAIS), digit symbol, digit span, Santa Ana motor coordination tests from the batteries of WHO-recommended neurobehavioral core test, as well as the reaction time, hand-eye motor coordination and Benton visual retention tests of the NES computerized test battery. The Profile of Mood Status (POMS) and a vocabulary test (synonym) were also included. Mean duration of exposure to organic solvents was 9.5 <plus-minus> 8.1 yrs. (range : 1-22). Toluene, mineral spirit and xylene were the major constituents of the paints used. Urine mandelic acids levels of workers was measured individually, and the mean value was 0.279<plus-minus>0.248 g/l (range was 0.063-0.7Results. From the results of pairwise comparisons of the symptoms of the age-matched pairs of exposed and referent subjects, dry and scal … More y skin, easily depressed without reason, coldness of hands and legs, easily irritated without reason, loss of appetite, dizziness and unsteadiness occurred statistatistically significantly more often among the exposed subjects than among the referents. Matched analysis showed that performance of the Santa-Ana coordination and digit symbol were significantly lower than those of controls. In multiple regression models, controlling for age, education, vocabulary and alcohol intake, a significant relation was found only between solvent exposure and poor performance in the Santa-Ana coordination test with higher value of one of scale of POMS ('Confusion').Conclusion. The results suggest that a symptom inquiry and POMS test are helpful for detecting the possible effects of exposure to low level of organic solvents. However no consistent pattern was observed in regard to the effects of organic solvent exposure on neurobehavioral function, which is coinncident with the type I toxic central nervous system disorder as classified by the WHO. Less

主题和方法。81名男性画家完成了一份症状问卷。对20名受试者进行了问卷调查和神经心理学检查，包括世界卫生组织推荐的神经行为核心测验组合中的方块设计测验（WAIS）、数字符号、数字广度、圣安娜运动协调测验，以及内斯计算机化测验组合中的反应时、手眼运动协调和本顿视觉保持测验。还包括情绪状态（POMS）和词汇测试（同义词）。有机溶剂暴露的平均持续时间为9.5 <plus-minus>- 8.1年（范围：1-22）。甲苯、矿油精和二甲苯是所用油漆的主要成分。分别测定工人尿中扁桃酸含量，平均值为0.279 <plus-minus>± 0.248g/l（范围为0.063- 0.7）。根据对年龄匹配的暴露和参照受试者的症状进行成对比较的结果， ...更多信息 皮肤干燥、无故抑郁、手脚冰凉、无故烦躁、食欲不振、头晕、站立不稳等症状，暴露组明显高于对照组。配对分析表明，圣诞老人的协调和数字符号的性能显着低于控制。在控制年龄、教育程度、词汇量和酒精摄入量的多元回归模型中，仅发现溶剂暴露与圣安娜协调测试中表现不佳之间存在显着关系，其中POMS量表之一（“困惑”）的值较高。结论。结果表明，症状询问和POMS测试有助于检测接触低浓度有机溶剂的可能影响。然而，在有机溶剂暴露对神经行为功能的影响方面没有观察到一致的模式，这与WHO分类的I型中毒性中枢神经系统障碍一致。少

项目成果

岸玲子、三宅浩次: "有機溶剤による中枢神経機能の障害心理・行動テストに基づく評価" 産業医学. 第32巻. 3-17 (1990)

Reiko Kishi、Koji Miyake：“基于心理和行为测试的有机溶剂对中枢神经系统功能的损害评估”工业医学第 32 卷 3-17 (1990)。

Kishi R. and Miyake H.: "Acute and chronic effects of organic solvents on the central nervous system --- Use of psychobehavioral performance tests in the assessment of toxicit" Jpn J Ind Health. 32. 3-17 (1990)

Kishi R. 和 Miyake H.：“有机溶剂对中枢神经系统的急性和慢性影响 --- 在毒性评估中使用心理行为表现测试”Jpn J Ind Health。

岸 玲子,三宅 浩次: "有機溶剤による中枢神経機能の障害・・・心理・行動テストに基づく評価" 産業医学. 32. 3-17 (1990)

Reiko Kishi、Koji Miyake：“有机溶剂引起的中枢神经系统功能障碍......基于心理和行为测试的评估”工业医学。32. 3-17 (1990)。

岸玲子, 三宅浩次: 産業医学.

Reiko Kishi、Koji Miyake：工业医学。

Kishi R,Harabuchi I,Katakura Y,Ikeda T and Miyake H.: "Newobehawioral effects of chronic occupational exposure to orgamic solvents among industiol paintens." Proceedingo of 4yh international Symposium on Newabehavional Methods and Effects in Occupational

Kishi R、Harabuchi I、Katakura Y、Ikeda T 和 Miyake H.：“工业油漆工人中长期职业接触有机溶剂的新行为影响”。