Absorption and Excretion of Fluorine in Humans Due to Differences in absorption Route and Chemical Form of Fluoride

由于氟化物吸收途径和化学形态的不同，人体对氟的吸收和排泄

• 批准号: 60480193
• 负责人: TSUNODA Humio
• 金额: $ 3.71万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480193/
• 关键词: Fluoride Metabolism; Gastrointestinal Absorption; Respiratory Absorption; Skin Absorption; Fluoride Mouth-rinsing; Serum Fluoride; Urinary Fluoride; フッ素の超微量分析; フッ素化合物; 経粘膜吸収; 尿中フッ素排泄; 生体内フッ素蓄積

With the advent of recent advances in the microanalysis of fluoride, it is now possible to determination with high accuracy trace amount of fluoride,such as those found in the serum. In this study, the Absorption of fluoride in humans due to differences in absorption route, such as gastrointestinal tract, Lung and Skin et al. and chemical from of various fluorides are investgated by using serum fluoride level as well as the commonly used urinary fluoride levels as an indicator of fluoride absorption.1) On the oral administration of fluoride ; The rate of NaF absorption through the gastrointestinal tracts was rapid and considerable. On the other hand, the absorption rate of CaF_2 was only 5-7% of the value shown by NaF,and AlF_3 was not absorbed. The reason for these difference depends on the acid-solubulity of various fluorides.2) On the respiratory absorption ; The absorption rate of fluoride through the respiratory tract has been studied for NaF aerosol, CaF_2 aerosol and gaseous HF. The rate are estimated at 23-26% for NaF, about 2% for CaF_2 and 10-80% for HF.3) On the skin absorption ; A comparative study was made to look into the rate of fluoride into the quinea pig skin following administration of HF, NH_4 HF and NaF solution. The skin absorption of hydrofluolic acid and ammonium hydrogen fluoride were rapid and severe, but the skin absorption of NaF solution was not occurred.

随着氟化物微量分析的最新进展，现在有可能高精度地测定痕量氟，如在血清中发现的那些。在本研究中，由于人体对氟的吸收途径不同，如胃肠道、肺和皮肤等。用血氟水平和常用尿氟水平作为氟吸收的指标，对各种氟化物的化学形态进行了研究。1)口服氟化物时，通过胃肠道吸收氟化物的速度快而可观。而CaF_2的吸收率仅为NaF的5-7%，AlF_3未被吸收。这些差异的原因取决于各种氟化物的酸溶度。2)呼吸吸收；研究了NaF气溶胶、CaF_2气溶胶和气态HF对氟化物通过呼吸道的吸收速率。在皮肤吸收方面，氟化钠约为23-26%，氟化钙约为2%，氟化氢约为10-80%。用氟化氢、氢氧化铵和氟化钠溶液对豚鼠皮肤进行了氟吸收的比较研究。氢氟酸和氟化氢铵的皮肤吸收迅速而严重，而氟化钠溶液未发生皮肤吸收。

项目成果

Kazuyoshi Itai: Studies in Environmental Science. 27. 25-29 (1986)

Kazuyoshi Itai：环境科学研究。

Noriko,TSUNODA: "Gastrointestinal Absorption of Fluoride in Humans- A Comparative Study of NaF and CaF_2" Studies in Environmental Science. 27. 389-394 (1986)

Noriko,TSUNODA：“人体氟化物的胃肠道吸收 - NaF 和 CaF_2 的比较研究”环境科学研究。

Shigenao,NAKAYA: "Absorption of Hydrogen Fluoride through the Skin as A Result of Hydrofluoric- Acid Burns" Fluoride. 21. (1988)

Shigenao，NAKAYA：“氢氟酸灼伤导致皮肤吸收氟化氢” 氟化物。

Humio,TSUNODA: Elsevier Science Publishers B.V. ( Amsterdam ). Fluoride Research 1986, 435 (1986)

Humio，TSUNODA：Elsevier Science Publishers B.V.（阿姆斯特丹）。

Shiro, SAKURAI: Fluoride. 21. (1988)

樱井白：氟化物。