Experimental study of factors and conuter measures on spinal cord circulation disturbance

1. 急性脊髓损伤，(1)用重物引起大鼠脊髓压迫损伤，(a)减压后脊髓血流出现高血压反应，但在1小时内恢复到损伤前水平，维生素E组（E组）持续3小时，而对照组（C组）持续3小时。(b)脊髓诱发potentisls显示复苏在E组大于在c组(c) Histologicaly,脊髓损伤较少,如出血或水肿,在E组比在c组(d)高水平的TBA-RS被压缩在两组损伤和维护24小时在c组,但在1小时内减少在E组(2)急性脊髓缺血损伤是由剪切大鼠胸主动脉。(a) e组再循环产生的高TBA-RS水平在30分钟内恢复到损伤前水平，而C组持续1小时。(b) ESP组恢复效果更显著。(1)蛛网膜下腔注射高岭土致犬脊髓脊髓空洞症；延迟CTM显示甲咪唑胺经髓质从蛛网膜下腔进入脊髓，提示csf -脊髓屏障受损。(2)荧光素、埃文斯蓝、离子镧、HRP等示踪剂经大鼠膜胶质转移至脊髓。（分子越小，通过的速度越快）。

1. Acute spinal cord lesion, (1) Compression injury of rat spinal cord was induced by placing a weight, (a) Spinal cord blood flow produced a hypertensive response after decompression, but restored to preinjury level within one hour in Vitamin E group(group E),while these of control group (group C) lasted by 3 hours. (b) The spinal cord evoked potentisls showed greater recovery in group E than in group C. (c) Histologicaly, the spinal cord showed less damage, such as bleeding or edema, in group E than in group C. (d) The high level of TBA-RS was produced in both groups by compression injury and maintained for 24 hours in group C, but decreased within 1 hour in group E. (2) Acute spinal cord ischemia lesion was made by clipping the thoracic aorta of rats. (a) High TBA-RS level produced by re-circulation was restored to preinjury level within 30 minutes in group E. but in group C lasted by 1 hour. (b) ESP provided more remarkable recovery in group E.2. Chronic spinal cord lesion (1) Syringomyelia of dog spinal cord was induced by subarachnoid injection kaolin; transmedullary passaage of metrizamide from the subarachnoid space to syrinx was shown by delayed CTM, suggesting CSF-spinal cord barrier damage, (2) Tracers such as florescein, Evans blue, ionic lanthanum and HRP was observed to transfer to spinal cord through membranous glia of rat. ( the smaller the molecule, the faster the passage).