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Functional significance of the parallel circuits of local nonspiking interneurons in crayfish motor systems

小龙虾运动系统局部非尖峰中间神经元并联电路的功能意义

基本信息

批准号：
61480016
负责人：
HISADA Mituhiko
金额：
$ 2.75万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

Functional roles of the parallel circuits of local nonspiking interneurons have been studied in the crayfish motor systems.(1) Equilibrium reflex The motoneuron activity during the uropod equilibrium reflex has been shown to be controlled by a set of local nonspiking interneurons. Some part of the descending statocyst information was transmitted to the motoneurons through these interneurons which also received excitatory input from the abdominal posture system. This observation indicates that the postural facilitation of the uropod equilibrium response is based on the synaptic interaction in the nonspiking interneurons.(2) Avoidance reaction When a mechanical stimulus is applied to the uropod, the animal displays an avoidance reaction which changes during the growth. The sensory information is transmitted to the motoneurons through a set of nonspiking interneurons organized in parallel. Individual interneurons make facilitatory, disinhibitory, disfacilitatory of inhibitory connection t … More o motoneurons. The final output seems to be determined by the balance of these circuit operation, and that the behavioral change is based on the change in that balance.(3) Abdominal posture movement A set of nonspiking interneurons were identified which were organized in parallel and controlled the activity of abdominal postural motoneurons. These interneurons inhibited the activity of slow extensor inhibitors and slow flexor excitors on both sides of the 4th abdominal ganglion, However, they had no effect on extensor excitors and flexor inhibitors. We concluded that these interneurons worked in ensuring the abdominal extension movement to occur by inhibiting the antagonistic flexion movement.The results indicate that the parallel circuits of local nonspiking interneurons are neuronal modulators of behavior. Further study is needed to examine the possibility that these interneurons are the site for other higher-order functions of the central nervous system such as learning and motivation. Less

在小龙虾运动系统中，研究了局部非发放中间神经元的并联回路的功能作用。(1)平衡反射在尾足平衡反射过程中，运动神经元的活动被证明是由一组局部非尖峰中间神经元控制的。部分下行平衡囊信息通过这些中间神经元传递给运动神经元，运动神经元也接受来自腹式系统的兴奋性输入。这一观察结果表明，姿势促进的尾足平衡反应的基础上的非尖峰中间神经元的突触相互作用。(2)回避反应当机械刺激施加到尾足类动物时，动物会显示出回避反应，该反应在生长过程中发生变化。感觉信息通过一组平行组织的非尖峰中间神经元传递给运动神经元。单个中间神经元使抑制性连接易化、去抑制、去易化， ...更多信息 o运动神经元最终的输出似乎是由这些电路操作的平衡决定的，并且行为变化是基于该平衡的变化。(3)腹部姿势运动一组nonspiking中间神经元被确定为平行组织，并控制腹部姿势运动神经元的活动。这些中间神经元对第4腹神经节两侧的伸肌慢抑制肌和屈肌慢兴奋肌的活动有抑制作用，而对伸肌慢抑制肌和屈肌慢抑制肌的活动无影响。我们的结论是，这些中间神经元通过抑制拮抗性屈曲运动来保证腹伸展运动的发生，这些结果表明，局部非发放中间神经元的平行回路是行为的神经元调节器。需要进一步的研究来检验这些中间神经元是中枢神经系统的其他高阶功能（如学习和动机）的可能性。少