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Exploratory study on the future research strategies and concepts for experimental analyses of animal behavior mechanisms: a comparative approach

动物行为机制实验分析的未来研究策略和概念的探索性研究：比较方法

基本信息

批准号：
61304006
负责人：
HISADA Mituhiko
金额：
$ 3.2万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

The research strategles the future study of the central nervous mechanisms underlying the animal behavior have been explored in a group of 12 neuroethologists whose backgrounds covered biochemistry, genetics, physiology, ethology and zoology. Consequently, both the experimental systems and the applied methods in their neuroethological research were so divergent that the results of individual researches might seem to be quite indifferent to each other. However,through extensive discussions at the group meetings held twice in the 3-year period of this research project, some common conclusions have emerged.(1) Intensive analysis of the neuronal circuits subserving several well-defined behavioral acts using the electrophysiological, neuroanatomical and genetical methods revealed that, while most of the newly found connections were consistent with the previous knowledge, not a few connectionw were also found which were inconsistent with the previous one. A number of newly found neuronal elements have been also encountered in the course of their study. The functional significance of these neurons is yet to be clarified in the future study. New viewpoints of the central integration of multimodal sensory information and the coordinative control of functionally related motor outputs might be the leading concept for these newly found inconsistency in neuronal connections.(2) Biogenic amines and peptides were found to modulate the action of neurotransmitters both at the neuromuscular junctions at the control synapses. In some cases, however, it is difficult to relate their action with the behavioral and physiological observation. These substances certainly play important roles in the behavioral control, but in order to understand their actual function, further study is needed on their action upon the neural circuit operation not only at the circuit level but also at the cellular levels.

本研究是由12位神经行为学家组成的研究小组，他们的背景涉及生物化学、遗传学、生理学、行为学和动物学，对动物行为的中枢神经机制的未来研究进行了探索。因此，神经行为学研究中的实验系统和应用方法是如此不同，以至于个体研究的结果似乎是相当无关紧要的。然而，通过在本研究项目的三年期间举行的两次小组会议上的广泛讨论，得出了一些共同的结论。(1)利用电生理学、神经解剖学和遗传学的方法对几种定义明确的行为行为的神经回路进行了深入的分析，结果表明，虽然大多数新发现的连接与以前的知识是一致的，但也发现了不少与以前不一致的连接。在他们的研究过程中也遇到了一些新发现的神经元元件。这些神经元的功能意义还有待于进一步的研究。多模态感觉信息的中枢整合和功能相关运动输出的协调控制的新观点可能是这些新发现的神经元连接不一致的主导概念。(2)生物胺和肽被发现可以调节神经递质在神经肌肉接头和控制突触的作用。然而，在某些情况下，很难将它们的行为与行为和生理观察联系起来。这些物质当然在行为控制中起着重要作用，但为了了解它们的实际功能，需要进一步研究它们对神经回路操作的作用，不仅在回路水平，而且在细胞水平。