权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Expulsion mechanism of adult-taeniid cestodes induced by mucosal responses of definitive hosts.

终宿主粘膜反应诱导成虫绦虫成虫的排出机制。

基本信息

批准号：
63480086
负责人：
KAMIYA Masao
金额：
$ 3.97万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

The taeniids are of interest not only because of their disease roll in domestic animals, some species are also of immense importance to Public health.To date, research on resistance to these cestodes has mainly focused on the intermediate host, and therefore on the larval cestode stage. The reasons for this were, that a suitable definitive host model has not been established, and experiments using the natural definitive host pose a grave threat to liuinan health, creating a barrier to safe investigative methods.To overcome this, this laboratory has investigated the possibility of using as experimental hosts for the five taeniid species Echinococcus multilocularis(Em), E. granulosus(Eg), Taenia crassiceps(Tc), T. saginata(Ts) and T. hydatigena(Th), the rodent species golden hamster(GH), Mongolian gerbil(MG) and 10 species of wild carnivorous rodents obtained from New Mexico, U.S.A.1) Tc/GH group. Adult worms developed in the small intestine of predonisolone treated and imtreated hamster … More s, and produced normal eggs.2) TC/MG group. In the treatment group worm expulsion was hindered as in the GH. A marked impediment to egg formation was noted.3) Em/GH group. Sexually mature worms were recovered from imtreated GH on day 25 post inoculation(PI). In inbred strains the presence of a defensive reaction to reinfection was suggested.4) Em/MG group. Susceptibility varied with age of host, and high worm recovery rate showed that the eggs liad Iiigli infectivity in this 1-iost.5) Em/Kangaroo rat etc. group. In tlie early stages of infection these rodents match the natural definitive host for worm recovery rate and worm development.Also, a complete substitute definitive host model for Em and Tc was established for the first time, and we could begin to explain phenomena such as the association between worm expulsion and antibody response.Apart from this, by achieving growth to sexual maturity of the human tapeworm T. saginata in treated Mongolian Gerbils, we have broken down the barriers to research in this field. Less

绦虫是感兴趣的，不仅是因为他们的疾病卷家畜，一些物种也是非常重要的公共health.To日期，对这些绦虫的抗性研究主要集中在中间宿主，因此在幼虫绦虫阶段。本实验室以多房棘球绦虫（Echinococcus multilocularis（Em））、棘球绦虫（E.颗粒绦虫（Eg）、粗头绦虫（Tc）、粗头绦虫（T. saginata（Ts）和T.棘球蚴（Th）、金黄仓鼠（GH）、蒙古沙鼠（MG）和10种美国新墨西哥州野生食肉啮齿动物。泼尼松龙处理和未处理仓鼠小肠内蠕虫 ...更多信息 2）TC/MG组。在治疗组中，与GH中一样，蠕虫排出受阻。3）Em/GH组：Em/GH组;在接种后第25天（PI），从未处理的GH中回收性成熟蠕虫。在近交系中，对再感染的防御反应的存在被排除。对不同年龄宿主的敏感性不同，高的虫体回收率表明该虫卵对1-los.5）Em/Kangaroo大鼠等群体具有较强的感染性。在感染的早期阶段，这些啮齿类动物与自然终末宿主在虫体恢复率和虫体发育方面相匹配，并首次建立了Em和Tc的完全替代终末宿主模型，我们可以开始解释诸如虫体排出和抗体反应之间的联系等现象。本研究为进一步研究沙鼠的抗肿瘤作用奠定了基础。少