ESTABLISHMENT AND USE OF ALTERNATIVE DEFINITIVE HOSTS FOR ECHINOCOCCUS
包虫病替代最终宿主的建立和使用
基本信息
- 批准号:02404083
- 负责人:
- 金额:$ 14.14万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (A)
- 财政年份:1990
- 资助国家:日本
- 起止时间:1990 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
An alternative definitive host model for echinococcus multilocularis was established following the successful recovery of gravid adult cestode from the small intesine of prednisolone-treated Mongolian gerbil and golden hamster after oral inoculation of protoscoleces. This paves the way for maintaining the complete life-cycle of the cestode in laboratory using rodents alone. The interspecies range of such "host permissiveness", that is, the ability to serve as alternative definitive host, for the cestode was examined using 10 species of wild rodents belonging to the family Heteromydae and sub-family Hesperomynae from the north American continent. Immature cestode were recovered from the Kangaroo rat and also from the pocket mouse. Of the 5 inbred strains of hamster evaluated, the AN strain was the most susceptible. Intestinal epithelial mucus was thought to prevent the initial establishment of the cestode in the mice, hamster and Mongilian gerbil. Differences in the number of mucosal mast cells between prednisolone-treated and non-treated animals suggest the defensive role of the cell against the parasite. Acquired immunity to reinfection of the cestode was also observed in hamster. Biliary cholesterol concentration of prednisolone-treated hamster might be an indicator for susceptibility to the cestode. In experiments involving E. granulosus infection in cortisone- treated hosts such as hamster, Mongolian gerbil, Akodon and Oryzomys, immature cestodes could be recovered only up to day 10 postinfection. By using the alternative definitive host model system and experimentally infected dogs, we have developed a reliable immunodiagnositic test for Echinococcus infection in dogs. The test involves the detection of heat- stable coproantigen by sandwich ELISA using a monoclonal antibody.
用强的松龙治疗的蒙古沙鼠和金黄地鼠口服原头节后,成功地从小肠中恢复了妊娠成虫,建立了另一种多房棘球绦虫的最终宿主模型。这为在实验室中单独使用啮齿动物维持绦虫的完整生命周期铺平了道路。利用来自北美大陆的10种野生啮齿动物,研究了这种寄主允许性的种间范围,即作为寄生虫的替代最终宿主的能力。从袋鼠和口袋鼠身上都发现了未成熟的寄生虫。在所评价的5个近交系仓鼠中,AN品系最敏感。肠道上皮粘液被认为可以阻止小鼠、仓鼠和蒙古沙鼠体内寄生虫的初步建立。强的松龙治疗的动物和未治疗的动物之间粘膜肥大细胞数量的差异表明该细胞对寄生虫的防御作用。在金黄地鼠身上也观察到了对线虫再感染的获得性免疫力。用强的松龙治疗的仓鼠胆汁中胆固醇浓度可能是头虫易感性的一个指标。在用可的松处理的宿主如仓鼠、蒙古沙鼠、Akodon和Oryzomys感染细粒棘球绦虫的实验中,未成熟的尾虫直到感染后第10天才能恢复。通过使用替代的最终宿主模型系统和实验感染的狗,我们发展了一种可靠的犬棘球绦虫感染的免疫诊断试验。该检测包括使用单抗通过夹心ELISA法检测耐热稳定的辅原抗原。
项目成果
期刊论文数量(32)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
UCHIDA,A.: "First record of Cysticercus longicollis (Taeniidae,Cestoda) from Japan." Jpn.J.Vet.Sci.52. 187-189 (1990)
UCIDA,A.:“来自日本的囊尾蚴(Taeniidae,Cestoda)的首次记录。”
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Uchida,A.: "First record of Cysticercus longicollis(Taeniidae,Cestoda)from Japan." Japanese Journal of Veterinary Science. 52. 187-189 (1990)
Uchida,A.:“来自日本的长尾囊尾蚴(Taeniidae,Cestoda)的首次记录。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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Sato,H.: "Extraintestinal strobilar development of immature Echinococcus multilocularis in laboratory rodents following intratracheal inoculation of the protoscoleces." Internarional Journal for Parasitology. 20. 689-692 (1990)
Sato, H.:“实验室啮齿类动物气管内接种原头节后,未成熟多房棘球绦虫的肠外球状发育。”
- DOI:
- 发表时间:
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- 影响因子:0
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Sato,H.: "Establishment,development and fecundity of Taenia crassiceps in the intestine of prednisolone-treated Mongolian gerbils and inbred mice." Journal of Helminthology. 64. 217-222 (1990)
Sato, H.:“粗头带绦虫在泼尼松龙治疗的蒙古沙鼠和近交小鼠肠道中的建立、发育和繁殖力。”
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- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Fujita,O.: "Susceptibility of some rodents to Taenia polyacantha and their mortality along the course of infection." Japanese Journal of Parasitology. 39. 284-289 (1990)
Fujita,O.:“一些啮齿动物对多棘绦虫的敏感性及其在感染过程中的死亡率。”
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- 影响因子:0
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KAMIYA Masao其他文献
KAMIYA Masao的其他文献
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{{ truncateString('KAMIYA Masao', 18)}}的其他基金
The role of transmitter hosts of Echinococcus multilocularis in its present endemicity and the countermeasure against infectious source animals to humans
多房棘球绦虫传播宿主在当前流行过程中的作用及传染源动物对人类的对策
- 批准号:
11359002 - 财政年份:1999
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Analysis of factors associating to parasitism and vaccine development of re-emerging Parasite, Echinococcus, using the alternative definitive host model
使用替代最终宿主模型分析与重新出现的寄生虫棘球蚴的寄生和疫苗开发相关的因素
- 批准号:
10680772 - 财政年份:1998
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Diversity of parasites and its maintenance mechnism in Central Asia
中亚地区寄生虫多样性及其维持机制
- 批准号:
07041156 - 财政年份:1995
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for international Scientific Research
Host exchange (Wild animal Domestic animal Human) and adaptive radiation in cestodes
绦虫中的宿主交换(野生动物、家畜、人类)和适应性辐射
- 批准号:
06454120 - 财政年份:1994
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Studies on the environmental adaptation of Echinococcus (Cyclophyllidea : Taeniidae) and its control
棘球绦虫(环叶纲:绦虫科)的环境适应及其防治研究
- 批准号:
03044016 - 财政年份:1991
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for international Scientific Research
Expulsion mechanism of adult-taeniid cestodes induced by mucosal responses of definitive hosts.
终宿主粘膜反应诱导成虫绦虫成虫的排出机制。
- 批准号:
63480086 - 财政年份:1988
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Control of Echinococcosis in the Northern Regions.
北方地区包虫病的防治。
- 批准号:
63044005 - 财政年份:1988
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for international Scientific Research
Establishment and application of the laboratory colony of Clethrionomys rufocanus bedfordiae susceptible to Echinococcus multilocularis for the antagonistic competion among taeniid species
多房棘球绦虫易感红毛密菌实验室种群的建立及其在绦虫类间拮抗竞争中的应用
- 批准号:
61880009 - 财政年份:1986
- 资助金额:
$ 14.14万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
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