The role of immune cells in controlling blood flow.

免疫细胞在控制血流中的作用。

• 批准号: DP160102642
• 负责人: Prof Erica Fletcher
• 金额: $ 25.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-06-30 至 2019-06-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102642
• 关键词: role; immune; cells; controlling; blood

The project aims to increase our understanding of how neurons in the central nervous system alter blood flow to meet their metabolic needs. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather, they rely on support cells to communicate the needs of neurons. This project aims to examine whether resident immune cells called microglia regulate blood vessels in response to neural activity. This knowledge would improve our understanding of how blood vessels are controlled in the retina and brain. The results may guide the development of novel ways of examining blood vessel function.

该项目旨在增加我们对中枢神经系统中的神经元如何改变血流以满足其代谢需求的理解。严格控制视网膜血管对于维持正常视力至关重要。与身体中的大多数血管不同，视网膜和大脑中的血管没有直接的神经控制。相反，它们依赖于支持细胞来传达神经元的需求。该项目旨在研究被称为小胶质细胞的常驻免疫细胞是否能调节血管对神经活动的反应。这些知识将提高我们对视网膜和大脑中血管如何控制的理解。这些结果可能会指导新的血管功能检查方法的发展。