Novel mechanisms for regulating the retinal vasculature

调节视网膜脉管系统的新机制

• 批准号: DP200102001
• 负责人: Prof Erica Fletcher
• 金额: $ 42.15万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-03-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102001
• 关键词: Novel; mechanisms; regulating; retinal; vasculature

Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel mechanism will be generated. This information is crucial for enhancing our understanding of how blood vessels are controlled in the retina and brain and will guide the development of novel ways of examining blood vessel function.

严格控制视网膜血管对维持正常视力至关重要。与身体中的大多数血管不同，视网膜和大脑中的血管不受直接的神经控制。相反，它们依靠支持细胞来传达神经元的需求。该项目旨在研究被称为小胶质细胞的常驻免疫细胞调节视网膜毛细血管以响应神经活动的机制。检验一种新机制的新知识将会产生。这些信息对于增强我们对视网膜和大脑中血管是如何控制的理解至关重要，并将指导开发检查血管功能的新方法。