Muller cell reactivity during diabetic retinopathy

糖尿病是导致工作人口失明的主要原因。在一些糖尿病患者中，视网膜内的血管增殖、出血或导致视网膜脱离。视网膜内导致血管增殖的潜在变化尚不清楚。导致视网膜血管变化的因素之一是视网膜内称为米勒细胞的细胞中生长因子的增加。米勒细胞对视网膜的正常功能至关重要，在糖尿病晚期被认为是异常的。它们也可能在糖尿病早期出现功能障碍，并可能在导致糖尿病早期变化方面发挥重要作用。因此，很好地了解穆勒细胞是如何变化的，以及它们变化的时间，对于更好地了解与糖尿病相关的缺陷至关重要。此外，对狄巴特体内发生的基本细胞变化的了解将有助于未来开发更具体的治疗剂。

Diabetes is the leading cause of blindness in the working population. In some patients with diabetes, blood vessels within the retina proliferate, haemorrhage or cause retinal detachment. The underlying changes within the retina that lead to the proliferation of blood vessels are not well understood. One of the factors that leads to changes in retinal blood vessels is an increase in growth factors from cells within the retina called Muller cells. Muller cells are vital for the normal function of the retina and are known to be abnormal late in diabetes. They may also be dysfunctional early in diabetes and could play a significant role in causing the early changes seen in diabetes. Therefore a good understanding of how Muller cells change and the time at which they change is vitally important to gain a better understanding of the defects that are associated with diabetes. Furthermore, an understanding of the basic underlying cellular changes that occur in dibaetes will aid the development of more specific therapeutic agents in the future.