Muller cell reactivity during diabetic retinopathy

糖尿病视网膜病变期间的 Muller 细胞反应

• 批准号: nhmrc : 350434
• 负责人: Prof Erica Fletcher
• 金额: $ 17.2万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/muller-cell-reactivity-diabetic-retinopathy/76368
• 关键词: Muller; cell; reactivity; during; diabetic

Diabetes is the leading cause of blindness in the working population. In some patients with diabetes, blood vessels within the retina proliferate, haemorrhage or cause retinal detachment. The underlying changes within the retina that lead to the proliferation of blood vessels are not well understood. One of the factors that leads to changes in retinal blood vessels is an increase in growth factors from cells within the retina called Muller cells. Muller cells are vital for the normal function of the retina and are known to be abnormal late in diabetes. They may also be dysfunctional early in diabetes and could play a significant role in causing the early changes seen in diabetes. Therefore a good understanding of how Muller cells change and the time at which they change is vitally important to gain a better understanding of the defects that are associated with diabetes. Furthermore, an understanding of the basic underlying cellular changes that occur in dibaetes will aid the development of more specific therapeutic agents in the future.

糖尿病是导致工作人群失明的主要原因。在一些糖尿病患者中，视网膜内的血管增生、出血或导致视网膜脱离。视网膜内导致血管增生的潜在变化尚未得到很好的理解。导致视网膜血管变化的因素之一是来自视网膜内称为穆勒细胞的细胞的生长因子的增加。米勒细胞对视网膜的正常功能至关重要，并且已知在糖尿病晚期是异常的。它们也可能在糖尿病早期功能失调，并可能在导致糖尿病早期变化方面发挥重要作用。因此，很好地了解Muller细胞如何变化以及它们变化的时间对于更好地了解与糖尿病相关的缺陷至关重要。此外，了解在dibalanine中发生的基本潜在细胞变化将有助于未来开发更特异性的治疗药物。