A novel role for microglia in neural maturation

小胶质细胞在神经成熟中的新作用

• 批准号: DP180101819
• 负责人: Prof Erica Fletcher
• 金额: $ 31.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101819
• 关键词: novel; role; microglia; neural; maturation

This project aims to determine the role that microglia have in maturation of cells of the retina called photoreceptors. High resolution microscopy combined with molecular and functional analysis will show the extent and type of contact between photoreceptors and microglia, the molecules released by microglia and the mechanism(s) by which microglia modify photoreceptors after birth. The knowledge gained in this project will provide critical information about how we see, and will have sustained impact on our understanding of the role of immune cells in the nervous system.

该项目旨在确定小胶质细胞在称为光感受器的视网膜细胞成熟中的作用。高分辨率显微镜结合分子和功能分析将显示光感受器和小胶质细胞之间接触的程度和类型，小胶质细胞释放的分子以及小胶质细胞在出生后修饰光感受器的机制。在这个项目中获得的知识将提供有关我们如何看待的关键信息，并将对我们理解免疫细胞在神经系统中的作用产生持续的影响。