Cyclic nucleotide induced degeneration in the vertebrate retina

环核苷酸诱导脊椎动物视网膜变性

• 批准号: nhmrc : 145735
• 负责人: Prof Erica Fletcher
• 金额: $ 13.1万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cyclic-nucleotide-induced-vertebrate-retina/97049
• 关键词: Cyclic; nucleotide; induced; degeneration; vertebrate

Retinitis Pigmentosa is a leading cause of human blindness that is currently untreatable. Elevated cyclic nucleotide levels have been shown to have a causal link with the degenerative process. This proposal will develop animal models of retinal degeneration as well as use a genetic mutant showing elevated cyclic nucleotides to identify the mechanism for retinal degeneration. In addition, potential therapeutic options will be investigated using currently available drugs.

视网膜色素变性是目前无法治愈的人类失明的主要原因。环核苷酸水平升高已被证明与退行性过程有因果关系。该提案将开发视网膜变性的动物模型，并使用显示环核苷酸升高的遗传突变体来确定视网膜变性的机制。此外，将使用现有药物研究潜在的治疗选择。