Molecular Pathology of Periodontal Diseases
牙周病的分子病理学
基本信息
- 批准号:63480421
- 负责人:
- 金额:$ 3.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1990
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Study 1. Neutrophil cell surface glycoprotein (LF-1 family) anomaly1) The quantity of LFA-1 family beta-subunit of the neutrophil cell surface glycoprotein expressed on the cell membrane was studied in 28 Patients with various types of periodontal disease by Western blotting and Flow cytometry using the monoclonal antibody against the beta-subunit.2) In patients with early-onset periodontitis, the LFA-1 family beta-subunit was not fully expressed on the cell surface even after the stimulation with fMLP.3) The LFA-1 family beta-subunit is proposed as a possible marker in a novel typing for a certain periodontal disease.4) The restriction fragment length polymorphism (RFLP) analysis of LFA-1 family beta gene may make a gene diagnosis of such a periodontal disease subgroup possible.Study 2. RFLP analysis of HLA genes1) The possibility of gene diagnosis for a specific periodontal disease subgroup was explored by the detection of variations in the HLA class II beta-chain genes.2) The RFLP analysis of HLA-DQbeta gene digested with Bam H1 revealed that genetic variation existed in 4 patients with early-onset periodontitis out of 96 subjects.3) Gene variations may be useful as markers for novel gene diagnosis for a certain subgroup of periodontal disease.Study 3. Case reports of families with early-onset periodontitis1) Out of 3 daughters with juvenile periodontitis and their parents with adult periodontitis, 4 persons except father did not raise the level of serum IgG against periodontopathic bacteria.2) A mother and elder daughter with early-onset periodontitis and periodontally healthy younger daughter revealed host defensive function of T cell activation.3) The neutrophils from a mother and elder daughter with early-onset periodontitis and a periodontally healthy younger daughter showed characteristically reduced chemotactic activity against fMLP.
研究1.中性粒细胞表面糖蛋白(LF-1家族)异常1)应用抗中性粒细胞表面糖蛋白LFA-1家族β亚基单克隆抗体,采用Western blotting和流式细胞术检测了28例不同类型牙周病患者细胞膜上LFA-1家族β亚基的表达量。LFA-1家族β-亚基即使在用fMLP刺激后也不能在细胞表面完全表达。3)LFA-1家族β-亚基被提出作为某种牙周病的新分型的可能标记。4)LFA-1家族β-亚基的限制性片段长度多态性(RFLP)分析。1家族β基因可能使牙周病亚群的基因诊断成为可能。HLA基因的RFLP分析1)通过检测HLA-II类β链基因的变异,探讨牙周病特定亚群基因诊断的可能性; 2)用BamH 1酶切HLA-DQ β基因,对96例早发性牙周炎患者进行RFLP分析,发现4例早发性牙周炎患者存在遗传变异。基因变异可作为牙周病特定亚群的新基因诊断标记。早发性牙周炎家系病例报告1)在3个患青少年牙周炎的女儿和他们患成人牙周炎的父母中,除父亲外,其余4人血清中抗牙周致病菌IgG水平均未升高。2)1例早发性牙周炎的母亲和大女儿以及牙周健康的小女儿均显示出T细胞活化的宿主防御功能。中性粒细胞从母亲和大女儿早发性牙周炎和牙周健康的小女儿表现出特征性的减少对fMLP的趋化活性。
项目成果
期刊论文数量(108)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
F.Nishimura.et al.: "A family study of a mother and daughter with increased susceptibility to earlyーonset periodontitis:microーbiological,host defensive,and genetic analyses." J.Periodontol.61. 755-765 (1990)
F. Nishimura.et al.:“对早发性牙周炎易感性增加的母亲和女儿的家庭研究:微生物、宿主防御和分析遗传分析。”J.Periodontol.61(1990) )
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- 影响因子:0
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- 通讯作者:
M. Kobayashi and Y. Murayama: "A case of periodontitis with a "risk factor" in neutrophil membrane glycoproteins" J. Dental Medicine. 31. 843-850 (1990)
M. Kobayashi 和 Y. Murayama:“中性粒细胞膜糖蛋白存在“危险因素”的牙周炎病例”J. Dental Medicine。
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- 影响因子:0
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H. Kurihara et al.: "Humoral immune response to an antigen from Porphyromomas Bgingivalis 381 in periodontal disease" Infect. Immun.
H. Kurihara 等人:“牙周病中对 Bgingivalis 381 抗原的体液免疫反应”感染。
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- 影响因子:0
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- 通讯作者:
高柴 正悟: "ヒト白血球抗原(HLA)遺伝子の制限断片長多型(RFLP)解析による歯周病病態の分子生物学的研究" 日歯周誌. 32. 386-401 (1990)
Shogo Takashiba:“利用人类白细胞抗原 (HLA) 基因的限制性片段长度多态性 (RFLP) 分析进行牙周疾病病理学的分子生物学研究”日本牙周杂志 32. 386-401 (1990)。
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MURAYAMA Yoji其他文献
MURAYAMA Yoji的其他文献
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{{ truncateString('MURAYAMA Yoji', 18)}}的其他基金
A study on the establishment of periodontal treatment for patients with insulin resistant diabetes mellitus.
胰岛素抵抗糖尿病患者牙周治疗方案建立的研究
- 批准号:
12470470 - 财政年份:2000
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Microbiological examination for periodontal therapy
牙周治疗的微生物学检查
- 批准号:
12557192 - 财政年份:2000
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Basic studies on adaptation the immune therapy to the patients with periodontal diseases by using synthetic peptides as an immunogen
以合成肽为免疫原对牙周病患者进行免疫治疗的基础研究
- 批准号:
09470425 - 财政年份:1997
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on the calcification by periodental ligament fibroblasts in the periodonta regeneration
牙周膜成纤维细胞钙化作用在牙周再生中的研究
- 批准号:
06454540 - 财政年份:1994
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Establishment of rapid method for detection of periodontitis-associated microorganisms
牙周炎相关微生物快速检测方法的建立
- 批准号:
06557102 - 财政年份:1994
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Molecular Basis of Leukocyte Adhesion Molecules in Early-onset Periodontitis Patients.
早发性牙周炎患者白细胞粘附分子的分子基础。
- 批准号:
03454441 - 财政年份:1991
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
The Role of Microorganisms in Periodontal Diseases
微生物在牙周病中的作用
- 批准号:
62304049 - 财政年份:1987
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Effects of periodontally related microorganisms on metabolism of human fibroblasts from gingivae with various forms of periodontal disease
牙周相关微生物对各种牙周病牙龈成纤维细胞代谢的影响
- 批准号:
60480413 - 财政年份:1985
- 资助金额:
$ 3.58万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)