High Resolution Mass Spectrometer with Nano UPLC System

蛋白质分析部门（Zentrallabbor für Proteinanalytik，ZfP）成立于2002年，位于慕尼黑路德维希-马克西米利安大学（LMU）的Adolf Butenandt研究所（ABI），是DFG资助的五个合作研究中心（413，594，596，646和TR 5）的中央服务部门。与此同时，ZfP已成为新生物医学中心（BMC）的第一个核心设施，并于2012年被纳入DFG的研究基础设施数据库（RI_00089_ZfP_München）。ZfP不仅向BMC的团体提供专业知识和服务，还向LMU内的其他团体提供专业知识和服务，并开展了许多国家和国际合作。除了蛋白质和多肽的常规分析外，ZfP的大部分工作是蛋白质和蛋白质混合物的详细分析以及翻译后修饰的映射和表征。因此，ZfP的一个主要目标是开发处理这些问题的新方法，并在常规分析中建立这些方法。为了保持ZfP作为LMU医学院的高效和成功的服务单位，ZfP的设备始终符合最高的技术标准至关重要。新的高分辨率质谱仪旨在取代过时的LC MS系统（Orbitap Classic），同时显着提高ZfP的深度蛋白质组分析和翻译后修饰以及蛋白质-蛋白质交联的表征能力。

The Protein Analysis Unit (Zentrallabbor für Proteinanalytik, ZfP) was established in 2002 at the Adolf Butenandt Institute (ABI) of the Ludwig-Maximilians-University (LMU) of Munich as a central service unit of five DFG funded Collaborative Research Centers (413, 594, 596, 646 and TR5). In the meantime, the ZfP has established itself as the first Core Facility of the new Biomedical Center (BMC) and was integrated into the research infrastructure database of the DFG in 2012 (RI_00089_ZfP_München). The ZfP provides its expertise and services not only to groups with the BMC but also to other groups within the LMU and entertains a number of national and international collaborations. In addition to the routine analysis of proteins and polypeptides, much of the work of the ZfP is the detailed analysis of proteins and protein mixtures and the mapping and characterization of post-translational modifications. Therefore, it is a major goal of the ZfP to develop new methods for dealing with these issues and to establish them in routine analysis. In order to maintain the ZfP as an efficient and successful service unit at the medical faculty of the LMU, it is crucial that the equipment of the ZfP always meets the highest technical standards. The new high resolution mass spectrometer is intended to replace an obsolete LC MS system (Orbitap Classic) and at the same time significantly improve the capabilities of the ZfP for deep proteome analysis and the characterisation of post-translational modifications as well as protein-protein crosslinks.