High-Resolution GC-MS System with EI and CI Ion Source Including Direct Inlet Probe

配备 EI 和 CI 离子源（包括直接进样探头）的高分辨率 GC-MS 系统

• 批准号: 439533235
• 金额: --
• 依托单位: Technische Universität Braunschweig
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/439533235?language=en
• 关键词: Resolution; GC; MS; System; EI

The development of synthetic methods, the isolation and characterization of volatile natural products and biosynthetic intermediates and the total synthesis of natural products is an important part of research at the Faculty of Life Sciences at TU Braunschweig. Accordingly, it is of utmost importance to replace the GC-HRMS system that is currently in use in the Central Section of Mass Spectrometry of the Chemical Institutes of TU Braunschweig, by a more modern and more powerful instrument.Regarding its performance (especially in terms of resolution and mass accuracy) the current system is no longer sufficient to meet the requirements in research performed at the chemical institutes, but also in pharmacy and biology. Already now – due to its age – the operational availability is severely limited. It will further decrease in future because spare parts will not be available any longer.The proposed GC-HRMS system should be equipped with an EI and a CI ion source. These methods will allow for the analysis of volatile and semi-volatile compounds that are often found as minor components in complex (biological) mixtures. Furthermore, it should be equipped with a direct inlet probe. Despite the relatively small quantity of samples such an accessory is crucial for some of the users. The presently available instrument for this type of measurements is outdated and needs to be shut down in due course. The new system must support significantly better mass accuracies in concert with appropriate resolution because the main focus of all the applications (in synthetic chemistry, but also in biology) will be the determination of empirical formulas of unknown compounds in complex matrices based on accurate masses.

合成方法的发展、挥发性天然产物和生物合成中间体的分离和表征以及天然产物的全合成是布伦瑞克工业大学生命科学学院研究的重要组成部分。因此，将目前在布伦瑞克工业大学化学研究所质谱中心使用的GC-HRMS系统替换为更现代、更强大的仪器是至关重要的。就其性能而言（特别是在分辨率和质量精度方面），目前的系统已不足以满足化学研究所的研究要求，也不足以满足制药和生物学的研究要求。现在，由于它的年代久远，可用性受到严重限制。将来会进一步减少，因为备件将不再可用。建议的气相色谱- hrms系统应配备EI和CI源。这些方法将允许分析挥发性和半挥发性化合物，这些化合物通常是复杂（生物）混合物中的次要成分。此外，它应该配备一个直接入口探头。尽管样品数量相对较少，但这种配件对一些用户来说至关重要。目前用于这类测量的仪器已经过时，需要在适当的时候关闭。新系统必须支持明显更好的质量精度和适当的分辨率，因为所有应用（在合成化学中，但也在生物学中）的主要焦点将是基于精确的质量确定复杂基质中未知化合物的经验公式。