High-Resolution GC-MS System with EI and CI Ion Source Including Direct Inlet Probe

配备 EI 和 CI 离子源（包括直接进样探头）的高分辨率 GC-MS 系统

• 批准号: 439533235
• 金额: --
• 依托单位: Technische Universität Braunschweig
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/439533235?language=en
• 关键词: Resolution; GC; MS; System; EI

The development of synthetic methods, the isolation and characterization of volatile natural products and biosynthetic intermediates and the total synthesis of natural products is an important part of research at the Faculty of Life Sciences at TU Braunschweig. Accordingly, it is of utmost importance to replace the GC-HRMS system that is currently in use in the Central Section of Mass Spectrometry of the Chemical Institutes of TU Braunschweig, by a more modern and more powerful instrument.Regarding its performance (especially in terms of resolution and mass accuracy) the current system is no longer sufficient to meet the requirements in research performed at the chemical institutes, but also in pharmacy and biology. Already now – due to its age – the operational availability is severely limited. It will further decrease in future because spare parts will not be available any longer.The proposed GC-HRMS system should be equipped with an EI and a CI ion source. These methods will allow for the analysis of volatile and semi-volatile compounds that are often found as minor components in complex (biological) mixtures. Furthermore, it should be equipped with a direct inlet probe. Despite the relatively small quantity of samples such an accessory is crucial for some of the users. The presently available instrument for this type of measurements is outdated and needs to be shut down in due course. The new system must support significantly better mass accuracies in concert with appropriate resolution because the main focus of all the applications (in synthetic chemistry, but also in biology) will be the determination of empirical formulas of unknown compounds in complex matrices based on accurate masses.

合成方法的发展，挥发性天然产物和生物合成中间体的隔离和表征以及天然产物的总合成是Tu Braunschweig生命科学学院研究的重要组成部分。据此，最重要的是要替换当前在Tu Braunschweig化学机构的质谱中心中使用的GC-HRMS系统，它通过一种更现代，更强大的仪器进行了更现代和更强大的仪器。将其性能（尤其是解决方案和质量准确性）不足以满足化学性能和化学性能的功能，但在化学上也不足以满足。由于其年龄，现在已经受到了严格限制的运营可用性。将来将进一步减少，因为备件将不再可用。拟议的GC-HRMS系统应与EI和C​​I ION源相等。这些方法将允许分析挥发性和半挥发性化合物，这些化合物通常被认为是复杂（生物）混合物中的次要成分。此外，它应等效于直接入口探针。尽管相对少量的样本对于某些用户来说，此类附件至关重要。目前可用于此类测量的工具已过时，需要在适当的时候关闭。新系统必须在适当分辨率的情况下协同合作地支持更高的质量精度，因为所有应用（合成化学和生物学中）的主要重点将是基于准确质量的复杂矩阵中未知化合物的经验公式的确定。