Glycosphingolipids of various human ovarian tumors

各种人卵巢肿瘤的鞘糖脂

基本信息

  • 批准号:
    03807109
  • 负责人:
  • 金额:
    $ 1.22万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1991
  • 资助国家:
    日本
  • 起止时间:
    1991 至 1992
  • 项目状态:
    已结题

项目摘要

1. Glycosphingolipids (GSLs) of Various Human Ovarian Tumors:Among the human ovarian tumors, mucinous cystadenocarcinoma, serous cystadenocarcinoma, and clear cell adenocarcinoma, the mucinous cystadenocarcinoma showed a unique GSL composition. More than 90% of the acidic GSL in the mucinous cystadenocarcinoma was comprised of sulfolipids, rarely detected in normal ovary and found in concentrations of less than 40% in the other types of ovarian tumors. By means of negative ion fast atom bombardment mass spectrometry (FABMS) and gas-liquid chromatography(GLC), the major sulfolipid in mucinous cystadenocarcinoma was confirmed as I^3SO_3-GalCer with N-cerebronyl phytosphingosine, rather than I^3SO_3-GalCer with N-nonhydroxy fatty acyl sphingosine, the major molecular species in the other ovarian cancers.2. a Monoclonal Antibody, MRG-1:A murine monoclonal antibody, MRG-1, established by immunizing mouse with human ovarian carcinoma-derived cells, reacted preferentially with the cells' Golgi complexes and microsome fractions, but not with the plasma membranes, whereas the antigen was distributed in the intercellular matrix of normal human cervical epithelium. The antigen was identified as neutral GSLs with blood group A-determinant by TLC-immunostaining. Using FABMS and NMR, the structure was found to be ceramide-Glc4-Gal3-GlcNAc4-Gal(2-Fuc)3-GalNAc3-Gal(2-Fuc)3-GalNAc, type IIIA GSLs.3. Galactosyltransferase Associated with Tumor (GAT):GAT was studied clinically in ovarian cancer patients. The GAT positive rate for different histologic types of ovarian carcinoma was relatively high for each type, e. g., 55.0% for clear cell carcinoma and 66.7% for endometrioid adenocarcinoma. In patients with benign diseases, in particular endometriosis, the GAT positive rate was lower than the positive rate with any other simultaneously definite markers. These results indicate the usefulness of GAT in distinguishing malignant from benign ovarian tumors.
1.各种人类卵巢肿瘤的鞘糖脂(GSL):在人类卵巢肿瘤、粘液性囊腺癌、浆液性囊腺癌和透明细胞腺癌中,粘液性囊腺癌表现出独特的GSL组成。粘液性囊腺癌中超过 90% 的酸性 GSL 由硫脂组成,在正常卵巢中很少检测到,在其他类型的卵巢肿瘤中浓度低于 40%。通过负离子快原子轰击质谱(FABMS)和气液色谱(GLC),证实粘液性囊腺癌中的主要硫脂为I^3SO_3-GalCer与N-脑酰基植物鞘氨醇,而不是I^3SO_3-GalCer与N-非羟基脂肪酰基鞘氨醇(N-非羟基脂肪酰基鞘氨醇)。 其他卵巢癌2. a 单克隆抗体,MRG-1:鼠单克隆抗体,MRG-1,通过用人卵巢癌来源的细胞免疫小鼠而建立,优先与细胞的高尔基复合体和微粒体部分反应,但不与质膜反应,而抗原分布在正常人宫颈上皮的细胞间基质中。通过TLC免疫染色,该抗原被鉴定为具有A型血型决定簇的中性GSL。使用FABMS和NMR,发现结构为神经酰胺-Glc4-Gal3-GlcNAc4-Gal(2-Fuc)3-GalNAc3-Gal(2-Fuc)3-GalNAc,IIIA型GSLs。3。肿瘤相关半乳糖基转移酶 (GAT):在卵巢癌患者中对 GAT 进行了临床研究。卵巢癌不同组织学类型的GAT阳性率相对较高,例如:例如,透明细胞癌为 55.0%,子宫内膜样腺癌为 66.7%。在良性疾病,特别是子宫内膜异位症患者中,GAT阳性率低于任何其他同时明确的标志物的阳性率。这些结果表明 GAT 在区分恶性和良性卵巢肿瘤方面的有用性。

项目成果

期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.Kiguchi: "Glycosphingolipids of various human ovarian tumors: A significantly high expression of I^3SO_3GalCer and Lewis antigen in mucinous cystadenocarcinoma." Cancer Research. 52. 416-421 (1992)
K.Kiguchi:“各种人类卵巢肿瘤的鞘糖脂:I^3SO_3GalCer 和 Lewis 抗原在粘液性囊腺癌中显着高表达。”
  • DOI:
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    0
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K.Kiguchi: "Clinical usefullness of two newly established tumor associated antigens(CA54-61AND CA602)in ovarian cancer." 日本癌治療学会雑誌. 26. 78- (1991)
K.Kiguchi:“两种新建立的肿瘤相关抗原(CA54-61 和 CA602)在卵巢癌中的临床实用性。”日本癌症治疗学会杂志 26. 78-(1991)。
  • DOI:
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    0
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K.Kiguchi: "Clinical usefullness of two newly established tumor associated antigens (CA54-61AND CA602) in ovarian cancer." 日本癌治療学会雑誌. 26. 78- (1991)
K.Kiguchi:“两种新建立的肿瘤相关抗原(CA54-61 和 CA602)在卵巢癌中的临床实用性。”日本癌症治疗学会杂志 26. 78-(1991)。
  • DOI:
  • 发表时间:
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    0
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木口 一成: "Analysis of glycosphingolipids in ovarian tumors." 日本産婦人科学会雑誌. 41. 1131- (1989)
Kazunari Kiguchi:“卵巢肿瘤中鞘糖脂的分析。”日本妇产科学会杂志 41。1131-(1989)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
木口 一成: "Analysis of glycosphingolipids in ovarian tumors" 日本産婦人科学会雑誌. 41. 1131 (1989)
Kazunari Kiguchi:“卵巢肿瘤中鞘糖脂的分析”日本妇产科学会杂志 41. 1131 (1989)。
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    0
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KIGUCHI Kazushige其他文献

KIGUCHI Kazushige的其他文献

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{{ truncateString('KIGUCHI Kazushige', 18)}}的其他基金

Optimization of chemotherapy of ovarian cancer as an indicator of transporter expression and glycolipid
作为转运蛋白表达和糖脂指标的卵巢癌化疗优化
  • 批准号:
    20591965
  • 财政年份:
    2008
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A trial at developing molecular-targeted therapy of ovarian cancer using a molecular chaperon heat shock protein(Hsp) as the target
以分子伴侣热休克蛋白(Hsp)为靶点开发卵巢癌分子靶向治疗的试验
  • 批准号:
    18591849
  • 财政年份:
    2006
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study of effect of a carbohydrate chain gene on the characteristics of ovarian cancer cells
糖链基因对卵巢癌细胞特性影响的研究
  • 批准号:
    13671755
  • 财政年份:
    2001
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis and Clinical Significance on the Carbohydrate Chain Gene related to the Peritoneal Dissemination of Ovarian Cancer.
卵巢癌腹膜播散相关糖链基因分析及临床意义。
  • 批准号:
    11671659
  • 财政年份:
    1999
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of the molecular bases and the expression of the Lewis^x sugar chain, which may account for the high dissemination potential.
对 Lewis^x 糖链的分子碱基和表达进行分析,这可能是其高传播潜力的原因。
  • 批准号:
    09671721
  • 财政年份:
    1997
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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  • 批准号:
    1940965
  • 财政年份:
    2019
  • 资助金额:
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Averting recurrent and resistant ovarian tumors
避免复发性和耐药性卵巢肿瘤
  • 批准号:
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卵巢肿瘤个体化研究与缺氧相关因素相关的新策略
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线粒体基因组改变在上皮性卵巢肿瘤中的作用
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卵巢肿瘤缺氧诱发因素分析,注重个体化治疗
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