Effects of Vessel Wall Elasticity on Blood Flow

血管壁弹性对血流的影响

• 批准号: 04670845
• 负责人: SEKI Junji
• 金额: $ 1.34万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670845/
• 关键词: Vessel Wall Elasticity; Pulsatile Flow; Turbulence Transition; Laser-Doppler Anemometer; Wave Propagation; Propagation Velocity; Network Architecture; Spontaneous Hypertension; 血管弾性; レーザ・ドップラ流速計; レイノルズ数

In vitro and in vivo experiments were conducted to study the effects of the vessel wall elasticity on the blood flow characteristics focusing on thegeneration and development of blood flow turbulence and on the propagation of flow pulse in microvessels, respectively.In in vitro experiments, a fully developed pulsatile flow (sinusoidal flow in addition to mean flow) was measured by a laser-Doppler anemometer. The velocity waveforms and the velocity profiles in the tube cross-section were obtained under various conditions of pulsatile flow. When the flow was not turbulent, the velodcity waveforms and the velocity proviles agreed well with the theoretical predictions. Regarding the turbulence transition, the centerline velocity was recorded as the mean Reynolds number was increased with a fixed frequency and amplitude of pulsation. The flow became turbulent in the deceleration phase when the mean Reynolds number was larger than a critical value, the transition Reynolds number. The transis … More ion Reynolds number was 2400 at the modulation Reynolds number of 880 and the freqyency parameter of 5.9. Considering the transision Reynolds number of steady flow was 2000, it means that the flow is stabilized under the pulsatile condition.In in vivo experiments, propagation of flow pulse was studied in microvascular networks of rat mesentery by a fiber-optic laser-Doppler anemometer microscope (FLDAM). The mean flow rate, amplitude of the flow pulsation, phase lag of the microvascular flow relative to the carotid arterial pressure were determined in arterioles, capillaries and venules. The arterio-venous distributions of the mean flow, flow amplitude and phase lag were analyzed based on an idealized model of the microvasculature. The difference observed in the distributions between spontaneously hypertensive rats (SHR) and normotensive control rats (WKY) were explained from the theoretical model by the rarefaction of small arterioles in SHR.Thepropagation velocity of flow pulse was also measured in arterioles. The elastic modulus of the vessel wall estimated from the propagation velocitywas in the range from 2x10^6 to 2x10^7 dyn/cm^2, which was in the same order of the elastic modulus for large arteries. Less

通过体外实验和体内实验研究了血管壁弹性对血流特性的影响，重点研究了血流湍流的产生和发展以及血流脉冲在微血管中的传播。在体外实验中，利用激光多普勒风速仪测量了充分发展的脉动流(除平均流外还有正弦流)。得到了不同脉动流条件下的速度波形和管段内的速度分布。在非湍动条件下，速度波形和速度分布与理论预测值吻合较好。对于湍流转变，在一定的脉动频率和幅值下，当平均雷诺数增加时，记录了中心速度。在减速阶段，当平均雷诺数大于一个临界值，即转变雷诺数时，流动变为湍流。TRANSIS…当调制雷诺数为880，频率参数为5.9时，多离子雷诺数为2400。考虑到定常流动的过渡雷诺数为2000，说明脉动条件下流动是稳定的。在活体实验中，利用光纤激光-多普勒风速计显微镜(FLDAM)研究了流动脉冲在大鼠肠系膜微血管网络中的传播。测定微动脉、毛细血管和小静脉的平均流速、血流脉动幅度、微血管血流相对于颈动脉压的相位滞后。根据理想化的微血管模型，分析了平均血流、血流幅度和相位滞后的动静脉分布。用自发性高血压大鼠(SHR)小动脉稀疏的理论模型解释了自发性高血压大鼠(SHR)与正常血压对照大鼠(WKY)血流分布的差异，并测量了小动脉内血流脉冲的传播速度。根据传播速度估算的血管壁弹性模量值在2×10~(-6)~2×10~(-7)dyn/cm~2之间，与大动脉的弹性模量值相同。较少

项目成果

関 淳二: "光ファイバ型レーザドップラ流速計顕微鏡による微小血管内脈波伝播速度の計測" 流れの計測. 11. 1-6 (1993)

Junji Seki：“使用光纤激光多普勒电流计显微镜测量微血管中的脉搏波传播速度”流量测量。

Seki, J.: "Propagation of Flow Pulse in Microvascular Networks" Jpn. J.Med. Electron. Biol. Eng.7. 73-81 (1993)

Seki, J.：“微血管网络中血流脉冲的传播”Jpn。

Junji Seki: "Propagation of Flow Pulse in Microvess els of Rat Mesentery" Biorheology. 29. 81- (1992)

Junji Seki：“大鼠肠系膜微血管中血流脉冲的传播”生物流变学。

Seki, J.: "Propagation of Flow Pulse in Microvessels of Rat Mesentery" Biorheology. 29. 81 (1992)

Seki, J.：“流脉冲在大鼠肠系膜微血管中的传播”生物流变学。

Seki, J.: "In vivo Measurements of Propagation Velocity of Flow Pulse in Microvessels of Rat Mesentery" Microcirculation Annual 1992. 8, Nihon Igakukan, Tokyo. 31-32 (1992)

Seki, J.：“大鼠肠系膜微血管中血流脉冲传播速度的体内测量”微循环年鉴 1992。8，日本医学馆，东京。