BASIC RESEARCH ON GENE THERAPY FOR HUMAN LEUKEMIAS BY ANTISENSE OLIGODEOXYNUCLEOTIDES

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1. Establishment of large-scale synthesizing and purification methods for antisense oligonucleosides phosphorothioates (1993)2. Evaluation of cell-membrane permeability of antisense oligonucleotides (1993)3. Examination of non-specific toxic effects on hematopoietic progenitors by antisense oligonucleotides (1993)4. Confirmation of clonal suppression on hemopoietic progenitor growth of chronic myeloid leukemia cells by BCR-ABL antisense oligonucleotides(1993, 1994)5. Evaluation of sequence specificity of BCR-ABL antisense oligonucleoside phosphorothioates on growth suppression of chronic myeloid leukemia cells (1994)6. BCR-ABL antisense oligonucleotides caused apoptotic cell death of chronic myeloid leukemia cells BV173, and confirmation of reduced production of p210 chimeric protein by these antisense oligomers (1994)7.Effects of BCR-ABL antisense oligonucleotides on the survival of BV173 leukemic cell transplanted mice are now under investigation (1994)