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The study of interstitial thermochemotherapy using Implant Heating System for oral cancer

种植体加热系统间质热化疗治疗口腔癌的研究

基本信息

批准号：
05807191
负责人：
TOHNAI Iwai
金额：
$ 1.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

Thermotolerance and local immune response in oral mucoas were observed for basic research of thermochem otherapy using Implant Heating System(IHS). Hsp40 was induced not only by heating but also sodium arsenite and prostaglandin in the same as hsp70. The extent of thermotolerance correlated well with the relative amount of hsp70 and 40. These results suggested that hsp40 is good predictor of thermotolerance in addition to hsp70. To examine effects of heat on immunologically responsive cells in oral mucosa, mouse tongue were heated by IHS.The densities of Langerhans cells and Thy-1-positive cells rapidly increased within 3 h after the treatment. Electron microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphcytic cells, suggesting an active response to the hyperthermia. In clinical trial, 19 patients with oral cancer were treated by thermochemotherapy using IHS.Thirteen patients of 19 underwent thermochemotherapy before operation. As a results, CR was observed in 11 patients and PR in 2 patients, and postoperative pathological examination showed no residual tumor cells in 12 patients. Other 6 patients were only umderwent thermochemotherapy without operation. As a results, CR was observed in all 6 patients. It was suggested that thermochemotherapy using IHS is promising as a new therapy for oral cancer, because it dose not necessitate surgery or radiotherapy and hence improves the QOL of patient with oral cancer.

为研究植入式加热系统（IHS）热化学治疗的基础，观察了口腔黏膜的热耐受性和局部免疫反应。热休克蛋白40的诱导不仅通过加热，而且亚砷酸钠和前列腺素在相同的热休克蛋白70。热耐受性的程度与热休克蛋白70和40的相对量相关。这些结果表明，热休克蛋白40是良好的预测耐热性除了热休克蛋白70。为探讨高温对小鼠口腔黏膜免疫反应细胞的影响，采用IHS法对小鼠舌进行高温处理，结果表明，高温处理后3 h内，小鼠舌黏膜Langerhans细胞和Thy-1阳性细胞密度迅速增加。电子显微镜证实舌上皮中的朗格汉斯细胞与淋巴细胞形成簇，表明对高温的积极反应。在临床试验中，对19例口腔癌患者采用IHS热化疗，其中13例在术前进行了热化疗。结果：11例患者CR，2例患者PR，12例患者术后病理检查无肿瘤细胞残留。其余6例仅行热化疗，未行手术治疗。结果，在所有6例患者中观察到CR。提示IHS热化疗不需手术或放疗，可提高口腔癌患者的生存质量，是一种很有前途的口腔癌治疗新方法。