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The Basic and Clinical Studies of Interstitial Hyperthermia of Brain Tumors using

脑肿瘤间质热疗的基础与临床研究

基本信息

批准号：
01480353
负责人：
TOHNAI Iwai
金额：
$ 4.22万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

l. Development of Implant Heating System (IHS)We observed that the Fe-Pt afloy (Fe : 73%i Pt : 27%, -Curie point : 68) is the best implant needle of the Implant Heating System (IHS). And we developed IHS for clinical study. The IHS consists of three parts : implant needle, induction coil and generator. The implant needle is 1.8mm in diameter and 15, 20, 25 mm in length, of which Curie pointa is set at 68. The induction coil is 30 cm in diameter, maximum magnetic field strength at the center of the coil is 16.7 Oe. And the generator. has 2.5 kill of maximum power, yielding the high frequency of 240 kHz.2. Experimental studiesWe have investigated intracellular translocation of hsp-70 during at moderate temperatures in HeLa cells. When cells were heated at temperatures above 41, hsp-70 translocated from the cytoplasm into the nuclei and apparently accumulated in nucleoli within, 10 min. At temperatures above 42, hsp-70 remained in the nuclei during, heating.Then we studied the histopathol … More ogical changes in rabbit tongue tumor model (VX-7 carcinoma) after single treatment of hyperthermia using IHS. The tumor tissue at 5mm apart from implant needle was showed coagulation necrosis. The necrotic lesion -was irregular shaped and tended to extend gradually toward the peripheral side of the tongue for 3 days.3. Clinical studiesSafe, repeated and longterm treatment of 25 cases of inoperable, recurrent brain tumors (Glioma : 13cases, Meta. : 7cases, Others : 5cases) have been made by the IHS. Before inducing hyperthermia, one or more implants were placed within the tumor by CT guided stereotaxis or inserted manually at craniotomy depending on the size of tumors. All the cases received repeated hyperthermia, combined with either radiotherapy or chemotherapy. The clinical response were 3 CR, 5 PR, 4 MR, 3 ST and 8 PD.Thirteen cases (tonque : 7cases, mouth floor : 2cases, gingiva : 2cases, palate : lcase lip : lcase) of oral cancer has been treated by IHS. Three cases were treated by IHS, irradiation and chemotherapy, and three cases were treated by IHS and chemotherapy (CDDP : 200mg, PEP : 70-80mg). The other 7 cases were treated by IHS, chemotherapy and operation. The clinical response were 9 CR and 4 PR. Less

L.种植体加热系统的研制我们观察到Fe-Pt合金（Fe：73%iPt：27%，-Curie point：68）是最好的种植体加热系统的种植针。我们开发了IHS用于临床研究。IHS由三部分组成：植入针、感应线圈和发生器。植入针的直径为1.8mm，长度为15、20、25 mm，居里点设定为68。感应线圈直径为30 cm，线圈中心的最大磁场强度为16.7 Oe。具有2.5杀死的最大功率，产生240千赫的高频。实验研究在中温条件下，HeLa细胞内热休克蛋白70（HSP-70）的转位。当细胞在41 ℃以上加热时，hsp-70在10分钟内从胞质转位到胞核，并明显聚集在核仁中，当温度高于42 ℃时，hsp-70在加热过程中仍留在胞核中。 ...更多信息兔舌肿瘤模型（VX-7癌）经IHS单次热疗后的生物学变化。距植入针5 mm处肿瘤组织凝固性坏死。坏死灶-呈不规则形，逐渐向舌周侧扩展，持续3 d.临床研究25例不能手术的复发性脑肿瘤（胶质瘤：13例，Meta.：7例，其他：5例）。在诱导热疗之前，根据肿瘤的大小，通过CT引导的立体定向术将一个或多个植入物放置在肿瘤内或在开颅术中手动插入。所有病例均接受反复热疗，并结合放疗或化疗。临床疗效：CR 3例，PR 5例，MR 4例，ST 3例，PD 8例。3例采用IHS加放疗加化疗，3例采用IHS加化疗（CDDP 200 mg，PEP 70- 80 mg）。其余7例采用IHS、化疗及手术治疗。临床反应为9例CR和4例PR。