Analysis of optimal dose of anticancer drug in superselective intra-arterial infusion using computational fluid dynamics based on biomedical engineering

为了明确口腔癌动脉灌注化疗中抗癌药物向肿瘤供血动脉或转移淋巴结的分布，采用计算流体力学方法对颈外动脉及其分支进行了血流模拟。为了准确模拟，我们应用了具有外围网络的0D模型，并使用颞浅动脉的血流进行模拟评估。该方法的误差在5%左右，为颈外动脉及其分支的患者特异性血流模拟奠定了基础。

To clarify distribution of anticancer drug to tumor feeding artery or metastatic lymph node in intra-arterial infusion for oral cancer, we developed blood flow simulation of the external carotid artery and its branch using computational fluid dynamics. For accurate simulation, we applied 0D model with peripheral network and assessment of the simulation was performed using blood flow of the superficial temporal artery. The error of this simulation was about 5%, and the base of patient-specific blood flow simulation of the external carotid artery and its branch was established.