Investigation on autonomic neurotoxicity of hazardous factors in environmental and occupational health

环境与职业健康危险因素的自主神经毒性调查

• 批准号: 06670401
• 负责人: MURATA Katsuyuki
• 金额: $ 1.28万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670401/
• 关键词: Environmental hazardous factors; Autonomic nervous system function; Heart rate variability (CV_<RR>); Parasympathetic function; Sympathetic function; Autonomic neurotoxicity; 心拍変動(CVRR); 有機溶剤; 鉛

To clarify the autonomic neurotoxicites of several hazardous factors in environmental and occupational health, such as lead, toluene, organic solvents including n-hexane, xylene and toluene, stirene, alcohol, vibrating tool operation and video display terminal (VDT) work, the electrocardiographic R-R interval variability (CV_<RR>) was measured in subjects exposed to such factors. Exposures to all the factors, except VDT work, are suggested to cause parasympathetic hypofunction ; in addition, lead and alcohol seem to affect the sympathetic activity. However, no significant effect of VDT work on the autonomic nervous system was found.Based upon an overview of research addressing the effects of environmental and occupational factors on the autonomic nervous system, the following finding were obtained :(1) Excluding the above factors, the effects of trichloroethene, carbon disulphide and mixed pesticides on autonomic nervous function have been investigated. Significant depression of the CV … More _<RR> has been shown in workers exposed to carbon disulphide and mixed pesticides, whereas there were no significant differences in any CV_<RR> parameters between workers with long-term exposure to trichloroethene and healthy controls.(2) Most of the factors appear to have affected the CV_<RR> mainly through depression of parasympathetic activity, suggesting that parasympathetic function is more susceptible to such factors in the environment and workplace than sympathetic function. On the other hand, decreased cardiac vagal tone has been reported to be associated with an increased risk of sudden cardiac death or coronary artery disease ; also, measurements of heart rate variability and the quantification of its spectral components are powerful predictors of cardiovascular morbidity and mortality. Therefore, particular attention should be directed to further discovery of hazardous factors, possibly causing some parasympathetic dysfunction in environmental and occupational health.(3) In the light of these data and previous data regarding the central and peripheral neurotoxicities, the cellular targets of lead in the autonomic nervous system are supposed to be the sympathetic and vagal nerves, and those of organic solvents and vibrating tool operation may be within the brainstem. Less

为了明确铅、甲苯、正己烷、二甲苯、甲苯等有机溶剂、苯乙烯、酒精、振动工具操作、视频显示终端（VDT）工作等环境和职业健康危害因素的自主神经毒性，对接触这些因素的受试者进行心电图R-R间期变异性（CV_<RR>）测量。除 VDT 工作外，暴露于所有因素均会导致副交感神经功能减退；此外，铅和酒精似乎会影响交感神经活动。然而，VDT工作对自主神经系统没有显着影响。通过对环境和职业因素对自主神经系统影响的研究综述，得到以下发现：(1)排除上述因素，考察了三氯乙烯、二硫化碳和混合农药对自主神经功能的影响。接触二硫化碳和混合农药的工人的 CV 显着降低，而长期接触三氯乙烯的工人和健康对照组之间的任何 CV_<RR> 参数均无显着差异。(2) 大多数因素似乎主要通过抑制副交感神经活动来影响 CV_<RR>，这表明副交感神经功能是 比交感功能更容易受到环境和工作场所中这些因素的影响。另一方面，据报道，心脏迷走神经张力降低与心源性猝死或冠状动脉疾病的风险增加有关；此外，心率变异性的测量及其频谱成分的量化是心血管发病率和死亡率的有力预测因素。因此，应特别注意进一步发现可能引起环境和职业健康副交感功能障碍的危险因素。(3)根据这些数据和以往有关中枢和周围神经毒性的数据，铅在自主神经系统中的细胞靶点应该是交感神经和迷走神经，而有机溶剂和振动工具操作的细胞靶点可能在脑干内。较少的

项目成果

村田勝敬,ほか: "Autonomic neurotoxicity of alcohoo assessed by heart rate variability" Journal of Autonomic Nervous System. 48. 105-111 (1994)

Katsutaka Murata 等人：“通过心率变异性评估酒精的自主神经毒性”《自主神经系统杂志》48. 105-111 (1994)。

Murata K,Araki S,et al.: "Autonomic neurotoxicity of alcohol assessed by heart rate variability." Journal of Autonomic Nerous System. 48. 105-111 (1994)

Murata K、Araki S 等人：“通过心率变异性评估酒精的自主神经毒性。”

村田勝敬,ほか: "Autonomic neurotoxicity of alcohol assessed by heart rate variability" Journal of Autonomic Nervous System. 48. 105-111 (1994)

Katsutaka Murata 等人：“通过心率变异性评估酒精的自主神经毒性”《自主神经系统杂志》48. 105-111 (1994)。

Murata K,Araki S,et al.: "Changes in autonomic function as determined by ECG R-R interval variability in sandal, shoe, and leather workers exposed to n-hexane, xylene, and toluene." Neurotoxicology. 15. 867-876 (1994)

Murata K、Araki S 等人：“接触正己烷、二甲苯和甲苯的凉鞋、鞋和皮革工人的心电图 R-R 间隔变异性确定了自主神经功能的变化。”

村田勝敬,ほか: "Autonomic and central nervous system effects of lead in female glass workers in China" American Journal of Industrial Medicine. 28. 233-244 (1995)

Katsutaka Murata 等人：“铅对中国女性玻璃工人的自主神经和中枢神经系统的影响”美国工业医学杂志 28. 233-244 (1995)。