Effect of Lymphokine on Saltatory Nerve Conduction in Single Myelinated Nerve Fibers.
Effect of Lymphokine on Saltatory Nerve Conduction in Single Myelinated Nerve Fibers.
批准号:
06670651
负责人:
KAJI Ryuji
金额:
$1.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1994
资助国家:
日本
项目状态:
已结题
起止时间:
1994 至 1995
中文摘要
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英文摘要
Antiganglioside antibodies are found in the axonal form of Guillain-Barre syndrome and multifocal motor neuropathy. Several studies indicated that they may produce conduction block through Na channel inactivation. To confirm this contention, we devised a method to analyze saltatory conduction in single myelinated fiber under the influence of the sera. Despite the premise, we found conduction block in only 2 out of 38 fibers examined with high-titer anti-GM1 rabbit serum. None showed conduction block by human sera. Only one out of 25 exhibited block after exposure to lymphokine produced by lymphocytes incubated with the anti sera. These finding do not support the view that these sera play an important role in the pathogenesis of these diseases.
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Koji R et al.: "Anti-GM1 antibodies and impairod blood-nerve barrier may interfere with remyelination in multifocal motor neuropathy" Muscle Nerve. 17. 108-110 (1994)
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Watanabe T et al.: "Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy." J. Neurol. Sci. 122. 140-143 (1994)
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通讯作者:
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共 15 条
Research on molecular pathogenesis and next-generation therapeutic agent for dystonia-parkinsonism
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Physiological Study on Conduction Block and anti GM1 Antibody in Multifocal Motor Neuropathy
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Effect of Na-K exchanger inhibitor bepridil on neuronal death -single fiber study-
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海外基金