Effect of Lymphokine on Saltatory Nerve Conduction in Single Myelinated Nerve Fibers.

淋巴因子对单髓神经纤维跳跃神经传导的影响。

• 批准号: 06670651
• 负责人: KAJI Ryuji
• 金额: $ 1.34万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670651/
• 关键词: lymphokine; anti-GM1 antibody; conduction block; multifocal motor neuropathy; Guillan-Barre syndrome; Na Channel; single fiber recording; anti-GM1 antibody; multi focal motor neuropathy; Guillan-Barre syndrome; single fiber recording; multifoca

Antiganglioside antibodies are found in the axonal form of Guillain-Barre syndrome and multifocal motor neuropathy. Several studies indicated that they may produce conduction block through Na channel inactivation. To confirm this contention, we devised a method to analyze saltatory conduction in single myelinated fiber under the influence of the sera. Despite the premise, we found conduction block in only 2 out of 38 fibers examined with high-titer anti-GM1 rabbit serum. None showed conduction block by human sera. Only one out of 25 exhibited block after exposure to lymphokine produced by lymphocytes incubated with the anti sera. These finding do not support the view that these sera play an important role in the pathogenesis of these diseases.

抗神经节苷脂抗体存在于格林-巴利综合征和多灶性运动神经病的轴突形式中。一些研究表明，它们可能通过钠通道失活而产生传导阻滞。为了证实这一论点，我们设计了一种方法来分析单个有髓纤维在血清影响下的跳跃传导。尽管有这样的前提，我们在用高效价抗GM1兔血清检查的38根纤维中只有2根发现了传导阻滞。无一例被人血清阻断传导。25人中只有1人在接触由抗血清孵育的淋巴细胞产生的淋巴因子后出现阻滞。这些发现不支持这些血清在这些疾病的发病机制中发挥重要作用的观点。

项目成果

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Watanabe T 等人：“超高 doce 甲基钴胺素促进实验性丙烯酰胺神经病中的神经再生”J.Neurol Sci。

Koji R et al.: "Anti-GM1 antibodies and impairod blood-nerve barrier may interfere with remyelination in multifocal motor neuropathy" Muscle Nerve. 17. 108-110 (1994)

Koji R 等人：“抗 GM1 抗体和受损的血神经屏障可能会干扰多灶性运动神经病”肌肉神经的髓鞘再生。

Mezaki T et al.: "Comparison of therapeutic efficacies of types A and F botulinum toxins for blepharospasm." Neurology. 45, March. 506-508 (1995)

Mezaki T 等人：“A 型和 F 型肉毒毒素治疗眼睑痉挛的疗效比较。”

Watanabe T et al.: "Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy." J. Neurol. Sci. 122. 140-143 (1994)

Watanabe T 等人：“超高剂量甲钴胺可促进实验性丙烯酰胺神经病的神经再生。”

Kaji R et al.: "Multifocal motor neuropathy" Ann Neurol. 35. 246-247 (1994)

Kaji R 等人：“多灶性运动神经病”Ann Neurol。