Physiological Study on Conduction Block and anti GM1 Antibody in Multifocal Motor Neuropathy

传导阻滞和抗GM1抗体在多灶性运动神经病中的生理学研究

• 批准号: 12672356
• 负责人: KAJI Ryuji
• 金额: $ 0.9万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672356/
• 关键词: Multifocal Motor neuropathy; Conduction Block; Threshold Electrotonus; Anti-GM1 Antibody; Depolarization; Hyperpolarization; Fasciculation; 筋萎縮性側索硬化症; 大量ガンマグロブリン静注療法; 閾値電気緊張法(TE法); chronic motor axonal neuropathy

Conduction block is an important functional consequence of demyelination whereby nervous transmission is abolished. Its mechanism has been discussed with respect to the loss of insulation due to disruption ofmyelin. Recent development of threshold tracking techniques, enabling non-invasive assessment of axonal membrane potentials and ion channels, has provided evidence that axonal excitability changes significantly contribute to conduction failure. This study based upon axo-glial interaction clarifies the pathomechanism of muscle fatigue and fasciculation associated with peripheral demyelination, and possibly explains selective motor involvement in multifocal motor neuropathy.

传导阻滞是脱髓鞘的一个重要功能性后果，由此神经传递被取消。其机制已被讨论方面的损失绝缘由于破坏髓鞘。最近开发的阈值跟踪技术，使轴突膜电位和离子通道的非侵入性评估，提供了证据，轴突兴奋性的变化显着有助于传导失败。这项研究的基础上轴胶质细胞的相互作用，阐明了肌肉疲劳和肌束震颤与周围脱髓鞘的病理机制，并可能解释选择性运动参与多灶性运动神经病变。

项目成果

Kaji R: "Activity-devendent conduction block in multifocal motor neuropathy"Brain. 123(Pt8). 1602-1611 (2000)

Kaji R：“多灶性运动神经病中的活动相关传导阻滞”大脑。

Kiernan MC: "Evidence for axonal membrane hyperolarization in multifocal motor neuropathy with conduction block"Brain. 125(in press). (2002)

Kiernan MC：“传导阻滞多灶性运动神经病中轴突膜过度极化的证据”大脑。

Kaji R: "Physiology of conduction block in demyelinating topathies: A new perspective based on axo-glial interaction"Muscle Nurve. 25 (in press). (2002)

Kaji R：“脱髓鞘性疼痛中传导阻滞的生理学：基于轴-神经胶质相互作用的新视角”Muscle Nurve。

梶龍兒: "多巣性運動ニューロパチー(Lewis-Sumner症候群)と伝導ブロック"神経治療学. 18(1). 35-46 (2001)

Ryuji Kaji：“多灶性运动神经病（刘易斯-萨姆纳综合征）和传导阻滞”《神经治疗学》18（1）35-46（2001）。

Yang Q: "Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathy"Brain. 127(Pt 6). 1149-1155 (2001)

杨Q：“链佐星诱导的实验性糖尿病神经病变中轴突向内整流异常”脑。