A Study about the eticlogy of dural AVF using rat AVF model

利用大鼠AVF模型研究硬脑膜AVF的病因学

• 批准号: 06671415
• 负责人: TERADA Tomoaki
• 金额: $ 1.28万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671415/
• 关键词: dural AVF; rat; venous hypertension; basic FGF; bacic FGF; estrogen; venous hypertension

Following points were studied using our venous hypertensive rats. 1) The mechanism of induced AVF by venous hypertension ; The appearance of basic fibroblast growth factor (bFGF) was examined by immunohistochemical technique for human dural sinus of dural AVF patients (Acta Neurochirurgica 1996 in press) and rat dural sinus of induced venous hypertension. bFGF was found in the sinus wall in human and rat dural sinus. This angiogenic factor may related to the development of dural AVF.2) The factor to modulate the development of dural AVF (estrogen) ; Estrogen is known to relate the development of human dural AVF.We examined the effect of estrogen for the development of rat dural AVFs. Induced venous hypertension rats with or without estrogen were compared at the rate of developing AVF.Any statistical significant difference was not revealed by this experiment. Therefore, we concluded estrogen itself did not affect the development of dural AVF.3) Anatomical study for the development of dural AVF ; Scanning electron microscopic study for the three dimensional angioarchitecture was studied for venous hypertension rat. Mercox (polymer) was injected into the rat venous sinus, but dessection of the rat venous sinus was too small to take out without injury. This study was abandoned.

使用我们的静脉性高血压大鼠研究了以下几点。1)应用免疫组织化学方法检测了人硬脑膜动静脉瘘患者（神经外科学报1996年出版）硬脑膜窦和静脉高压大鼠硬脑膜窦中碱性成纤维细胞生长因子（bFGF）的表达。bFGF在人和大鼠的硬脑膜窦壁中被发现。2）调节硬脑膜AVF发生的因子（雌激素）：雌激素与人硬脑膜AVF的发生有关。本实验比较了雌激素诱导的静脉高压大鼠AVF的发生率，结果表明，雌激素诱导的静脉高压大鼠AVF的发生率与未诱导的静脉高压大鼠AVF的发生率无显著差异。结论：雌激素本身并不影响硬脑膜AVF的发生。3）硬脑膜AVF发生的解剖学研究;静脉高压大鼠硬脑膜AVF血管三维构筑的扫描电镜研究。将Mercox（聚合物）注射到大鼠静脉窦中，但大鼠静脉窦的切割太小，无法在无损伤的情况下取出。这项研究被放弃了。

项目成果

T.Terada et al: "Dual microcatheter and guidewire snare technique for retrieval of intravascular foreign body" technical note. Neuroradiology. 38. 615-617 (1996)

T.Terada 等人：“用于取出血管内异物的双微导管和导丝圈套器技术”技术说明。

T.Terada,etal: "Tramsluminal an ofplasty for arteroscliretic dsease if the ditcl certetral and bars lan ant cies" Jownal of Neurolgy,Neuriuery and Prgchiatry. in press. (1996)

T.Terada 等人：“如果 Ditcl certetral 和 Bars lan ant cies，则用于治疗动脉硬化性疾病的腔内成形术”Jownal of Neurology、Neuriuery and Prgchiatry。

T.Terada et al: "The role of angiogenic factor bFGF in the development of dural AVFs" Acta Neurochirur. 138. 877-883 (1996)

T.Terada 等人：“血管生成因子 bFGF 在硬脑膜 AVF 发育中的作用”Acta Neurochirur。

T.Terada: "Clincal use of mechanical ditachable cools for demth AVF" Americal Journal of Nernadiclogy. (in press). (1996)

T.Terada：“临床使用机械可拆式冷却器治疗 AVF”美国神经学杂志。

T.Terada et al: "Clinical use of mechanical detachable coils for dural arteriovenous fistula" AJNR. 17. 1343-1348 (1996)

T.Terada 等人：“机械可拆卸线圈在硬脑膜动静脉瘘中的临床应用”AJNR。