Basic and clinical research of endovascular therapy for intracranial atherosclerosis lesions

颅内动脉粥样硬化病变血管内治疗的基础与临床研究

• 批准号: 13671455
• 负责人: TERADA Tomoaki
• 金额: $ 2.5万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671455/
• 关键词: intracranial artery; atherosclerosis; endovascular therapy; stent; atherosclerosis; intracronical artery; PTA; stent; endovascular therapy; brain; intracranical artery; bFGF; VEGF; cerebral artory; compls cation

1)Patency of the perforation artery after stent placement for the intracranial artery : In atherosclerosis induced rabbits, the orifice of the lumbar artery showed narrowing due to the proliferation of the intima around stent strut. However, most of cases, the lumbar artery was patent. These changes were different from those seen in normal rabbits.2)Results of clinical cases: 31 cases with intracranial atherosclerotic stenosis were treated with stenting. In three cases with total occlusion, one case showed re-occlusion in spite of the successful stenting and two cases showed restenosis. The rate of abnormality demonstrated in diffusion weighted MRI was small in number compared with carotid stenting. In 26 cases, long-term patency and stroke prevention was confirmed. Form these points, intracranial stenting was safe and effective.3)PVA coated covered stent : VEGF and bFGF were dissolved in the PVA polymer and released after stent placement. However, these materials were released within 24 hours. Slower release may be preferable for clinical use.

1)颅内动脉支架置入后穿孔动脉的通畅：动脉粥样硬化诱导家兔，由于支架支架周围内膜增生，腰动脉孔口变窄。然而，大多数情况下，腰动脉通畅。这些变化与正常家兔不同。2)临床病例结果：31例颅内动脉粥样硬化性狭窄行支架植入术。在3例完全闭塞的病例中，1例在支架置入成功后出现再闭塞，2例出现再狭窄。与颈动脉支架置入术相比，弥散加权MRI显示的异常率较少。26例经证实长期通畅，可预防脑卒中。由此可见，颅内支架置入术是安全有效的。3)PVA涂层覆膜支架：VEGF和bFGF溶解在PVA聚合物中，支架置入后释放。然而，这些材料在24小时内就发布了。缓释可能更适合临床使用。

项目成果

寺田友昭: "症例から学ぶ脳血管内手術"メヂィカ出版. 316 (2001)

寺田智明：《从病例中学到的脑血管内手术》Medica Publishing 316（2001）。

Tomoaki terada, et al.: "Results of Endovascular Treatment of Internal Carotid Artery Stenoses With a Newly Developed Balloon Protection Catheter"Neurosurgery. 53. 617-625 (2003)

Tomoaki terada 等人：“使用新开发的球囊保护导管进行血管内治疗颈内动脉狭窄的结果”神经外科。

T.Terada: "Combined Surgery and Endovascular Stenting for Basilar Artery Stenosis Refractory to Balloon Angioplasty : Technical Case Report"Acta Neurochir. 143. 511-516 (2001)

T.Terada：“联合手术和血管内支架治疗球囊血管成形术难治性基底动脉狭窄：技术案例报告”Acta Neurochir。

Tomoaki Terada: "Endovascular therapy for stenoses of the petrous caver nous portion of the intaralcarotid artery : PTA componed with steart plocement"Journal of Neurosurgery. 98. 491-497 (2003)

Tomoaki Terada：“颈内动脉岩部海绵窦狭窄的血管内治疗：PTA 与 stear plocement 组合”《神经外科杂志》。

T.Terada: "Endovascular therapy stenosis of the petrous or cavernous portion of the internal carotid artery : percutaneous transluminal angioplasty compared with stent placement"J. Neurosurgery. 98. 491-497 (2003)

T.Terada：“颈内动脉岩部或海绵状部分的血管内治疗狭窄：经皮腔内血管成形术与支架置入术的比较”J。