IXdent: Integrative X-ray techniques for chemical and structural characterizations of dental interzones

IXdent：用于牙齿间带化学和结构表征的综合 X 射线技术

• 批准号: 443841418
• 负责人: Professorin Dr. Birgit Kanngießer
• 金额: --
• 依托单位: Gemeinsame Forschungsgruppe Kombinierte Röntgenmethoden im BLiX und BESSY II - SyncLab
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/443841418?language=en
• 关键词: IXdent; Integrative; ray; techniques; chemical

Dental treatment includes restoration of degraded tooth tissue with artificial non-degradable materials with the aim of achieving long-lasting mechanical and aesthetic durability. Inevitably a thick interface (interzone) is formed between healthy tooth tissue and dental restoration. We identify the transition region between filling and tooth tissue as a distinct region that we henceforth name 'dental interzone', where composition is different from both the filling and dental tissue that comprise the filling. Thus, dental interzones comprise complex micro-geometries and chemical gradients, between a variety of dental materials and the hierarchical structure of natural hard tissues such as enamel or dentin. Degradation in such interzones is often the reason for restoration failure and a need for retreatment.In dental research there have been limited methodological studies on material composition instability, ageing and changes and effects on the immediate vicinity of interzones between filling and tooth substrate. Tracking of dynamic degradation in the juxtaposed materials is challenging, as they differ in main constituents (light elements prevail in the natural tooth tissue, whereas heavy elements are typical for fillings), density and structure. The aim of this project is to advance a multi-modal quantitative imaging methodology adapted to dental interzones by coupling synchrotron X-ray refraction radiography (SXRR) and tomography (SXRCT) as well as micro X-ray CT imaging (µXCT) with micro-X-ray fluorescence (µXRF) in 2 and 3 dimensions. For this purpose, the used methods will be adapted to the objects of investigation, the 3D data sets will be coupled (registered) and quantitative considerations including uncertainty evaluations will render the methodology into a true analytical tool.This development will pave the way to mapping tooth restoration failure and help understand predictable changes close to and around the interzones between dental tissue and artificial filling material. This is an important step towards controlling unwanted chemical and structural/density degradation and might become a new standard methodological instrument in dental research. The ultimate goal in the future is to support and enhance clinical treatment procedures.

牙科治疗包括用人工不可降解材料修复退化的牙齿组织，目的是实现持久的机械和美学耐久性。在健康牙齿组织和牙齿修复体之间不可避免地形成厚的界面（中间区）。我们将填充物和牙齿组织之间的过渡区域确定为一个独特的区域，此后我们将其命名为“牙齿间区”，其中组成不同于填充物和组成填充物的牙齿组织。因此，牙科中间区包括在各种牙科材料和天然硬组织如牙釉质或牙本质的分级结构之间的复杂的微观几何形状和化学梯度。降解在这样的interzones往往是修复失败的原因，并需要retreatment.In牙科研究中，有有限的方法学研究材料组成的不稳定性，老化和变化和影响之间的填充和牙齿基质的interzones的紧邻。跟踪并列材料的动态降解具有挑战性，因为它们在主要成分（轻元素在天然牙齿组织中占主导地位，而重元素通常用于填充物），密度和结构方面存在差异。该项目的目的是通过耦合同步加速器X射线折射照相术（SXRR）和断层摄影术（SXRCT）以及二维和三维微X射线荧光（µXRF）的微X射线CT成像（µXCT），推进适用于牙科中间区域的多模态定量成像方法。为此，所使用的方法将适用于调查对象，3D数据集将被耦合（注册）和定量考虑，包括不确定性评估将使该方法成为一个真正的分析工具。这一发展将为绘制牙齿修复失败铺平道路，并有助于了解牙齿组织和人工填充材料之间的可预测变化。这是控制不必要的化学和结构/密度降解的重要一步，并可能成为牙科研究中的新标准方法工具。未来的最终目标是支持和加强临床治疗程序。